THE NUCLEOTIDE-SEQUENCE OF THE L-GENE OF MARBURG VIRUS, A FILOVIRUS - HOMOLOGIES WITH PARAMYXOVIRUSES AND RHABDOVIRUSES

被引:69
作者
MUHLBERGER, E
SANCHEZ, A
RANDOLF, A
WILL, C
KILEY, MP
KLENK, HD
FELDMANN, H
机构
[1] UNIV MARBURG,INST VIROL,W-3550 MARBURG,GERMANY
[2] CTR DIS CONTROL,DIV VIRAL & RICKETTSIAL DIS,SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333
关键词
D O I
10.1016/0042-6822(92)90456-Y
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The nucleotide sequence of the L gene of Marburg virus, strain Musoke, has been determined. The L gene has a single long open reading frame encoding a polypeptide of 2330 amino acids (MW 267,175) that represents the viral RNA-dependent RNA polymerase. The putative transcription start signal (3′ CUACCUAUAAUU 5′) and the termination signal (3′ UAAUUCUUUUU 5′) of the gene could be identified. Computer-assisted comparison of the L protein with L proteins of other nonsegmented negative-stranded RNA viruses (Paramyxoviridae: Sendai virus, Newcastle disease virus, human parainfluenza 3 virus, measles virus, human respiratory syncytial virus; Rhabdoviridae: vesicular stomatitis virus, rabies virus) revealed significant homologies primarily in the N-terminal half of the proteins. We have identified three common conserved boxes (A, B, and C) among filo-, paramyxo-, and rhabdovirus L proteins, which are probably involved in the polymerase function. The L proteins can be divided into an N-terminal half, which seems to accomodate the common enzymatic sites, and a C-terminal half carrying virus specific peculiarities. The data presented here suggest a common evolutionary history for all nonsegmented negative-stranded RNA viruses and show that filoviruses are more closely related to paramyxo- than to rhabdoviruses. © 1992.
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页码:534 / 547
页数:14
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