THE EFFECT OF FREE-RADICALS INDUCED BY PARAQUAT AND COPPER ON THE INVITRO DEVELOPMENT OF PLASMODIUM-FALCIPARUM

被引：9
作者：
MARVA, E [1 ]
CHEVION, M [1 ]
GOLENSER, J [1 ]
机构：
[1] HEBREW UNIV JERUSALEM,DEPT CELLULAR BIOCHEM,JERUSALEM,ISRAEL
来源：
FREE RADICAL RESEARCH COMMUNICATIONS | 1991年 / 12-3卷
关键词：
MALARIA; PARAQUAT; TRANSITION METALS; OXIDANT STRESS;
D O I：
10.3109/10715769109145778
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of transition metals in paraquat toxicity was studied in cultures of Plasmodium falciparum. We showed that addition of copper led to an enhancement of the plasmodium killing, whereas addition of chelating agents. such as desferrioxamine and diethylenetriamine pentaacetic acid markedly reduced the toxic effects. Parsitized G6PD deficient erythrocytes were more sensitive than parasitized normal eryth-rocytes to copper and to the combination of copper and paraquat. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：137 / 146
页数：10
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