A CELL-SURFACE PROTEIN THAT BINDS AVIAN HEPATITIS-B VIRUS-PARTICLES

被引:78
作者
KUROKI, K
CHEUNG, R
MARION, PL
GANEM, D
机构
[1] UNIV CALIF SAN FRANCISCO,MED CTR,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143
[2] STANFORD UNIV,DEPT MED,DIV INFECT DIS,STANFORD,CA 94305
[3] KANAZAWA UNIV,INST CANC RES,KANAZAWA,ISHIKAWA 920,JAPAN
关键词
D O I
10.1128/JVI.68.4.2091-2096.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We have identified a 180-kDa cellular glycoprotein (gp180) that binds with high affinity to duck hepatitis B virus (DHBV) particles. The protein was detected by coprecipitating labeled duck hepatocyte proteins with virions or recombinant DHBV envelope proteins, using nonneutralizing monoclonal antibodies to the virion envelope. Binding of gp180 requires only the pre-S region of the viral large envelope protein, since recombinant fusion proteins bearing only this region efficiently coprecipitate gp180. The DHBV-gp180 interaction is blocked by two independent neutralizing monoclonal antibodies. The protein is found on both internal and surface membranes of the cell, and the species distribution of gp180 binding activity mirrors the known host range of DHBV infection. Functional gp180 is expressed in a wide variety of tissues in susceptible ducks.
引用
收藏
页码:2091 / 2096
页数:6
相关论文
共 26 条
[11]  
KORBA BE, 1986, J VIROL, V58, P1
[12]   LYMPHOID-CELLS IN THE SPLEENS OF WOODCHUCK HEPATITIS VIRUS-INFECTED WOODCHUCKS ARE A SITE OF ACTIVE VIRAL REPLICATION [J].
KORBA, BE ;
WELLS, F ;
TENNANT, BC ;
COTE, PJ ;
GERIN, JL .
JOURNAL OF VIROLOGY, 1987, 61 (05) :1318-1324
[13]   NOVEL N-TERMINAL AMINO-ACID SEQUENCE REQUIRED FOR RETENTION OF A HEPATITIS-B VIRUS GLYCOPROTEIN IN THE ENDOPLASMIC-RETICULUM [J].
KUROKI, K ;
RUSSNAK, R ;
GANEM, D .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) :4459-4466
[14]  
Kuroki K., UNPUB
[15]   NUCLEOTIDE-SEQUENCE OF A CLONED DUCK HEPATITIS-B VIRUS GENOME - COMPARISON WITH WOODCHUCK AND HUMAN HEPATITIS-B VIRUS SEQUENCES [J].
MANDART, E ;
KAY, A ;
GALIBERT, F .
JOURNAL OF VIROLOGY, 1984, 49 (03) :782-792
[16]  
MARION PL, 1988, PROG MED VIROL, V35, P43
[17]  
MARION PL, UNPUB
[18]   IDENTIFICATION AND CHEMICAL SYNTHESIS OF A HOST-CELL RECEPTOR-BINDING SITE ON HEPATITIS-B VIRUS [J].
NEURATH, AR ;
KENT, SBH ;
STRICK, N ;
PARKER, K .
CELL, 1986, 46 (03) :429-436
[19]   HUMAN-LIVER PLASMA-MEMBRANES CONTAIN RECEPTORS FOR THE HEPATITIS-B VIRUS PRE-S1-REGION AND, VIA POLYMERIZED HUMAN-SERUM ALBUMIN, FOR THE PRE-S2-REGION [J].
PONTISSO, P ;
PETIT, MA ;
BANKOWSKI, MJ ;
PEEPLES, ME .
JOURNAL OF VIROLOGY, 1989, 63 (05) :1981-1988
[20]   INFECTION AND UPTAKE OF DUCK HEPATITIS-B VIRUS BY DUCK HEPATOCYTES MAINTAINED IN THE PRESENCE OF DIMETHYL-SULFOXIDE [J].
PUGH, JC ;
SUMMERS, JW .
VIROLOGY, 1989, 172 (02) :564-572