Apoptotic Activity of Withania Coagulans Methanolic Extract in Cancer Cells Using Rats and Hela Cell Line

被引：0

作者：

Qureshi, Sadia ^{[1
]}

Aziz, M. Tahir ^{[1
]}

Qazi, M. H. ^{[1
]}

Saqib, Tahira ^{[1
]}

机构：

[1] Rashid Latif Med Coll, Dept Biochem, Lahore, Pakistan

来源：

PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES | 2015年 / 9卷 / 01期

关键词：

Apoptosis; withania coagulans & cancer cells;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The resistance of cancer to conventional therapies has inspired the researchers to search for novel strategies (3). Advances in molecular biology have helped to understand the mechanisms responsible for cell turnover and how tumors evade cell death. By exploring this knowledge, different strategies for treating malignancies have been planed that are based on restoration of natural pathways for cell demise. Methods: Anti cancer and apoptotic role of methanolic extract of withania coagulans was evaluated in this study. The extract was applied on both, the experimental animals in which carcinogens were applied on their skin to introduce cancerous lesions and the hela cell lines. Both responded well. Conclusion: The extracts of Withania coagulans can be used to formulate anti-cancer drugs and can replace many anticancer drugs, which are synthetic in nature and induce immense side effects within the body. Advance studies on this herb will conclude more about its anti-cancerous and apoptotic nature.

引用

页码：123 / 127

页数：5

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