THAPSIGARGIN BLOCKS THE INDUCTION OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES

被引：143
作者：
HARVEY, J
COLLINGRIDGE, GL
机构：
[1] Department of Pharmacology, The Medical School, University of Birmingham, Birmingham
来源：
NEUROSCIENCE LETTERS | 1992年 / 139卷 / 02期
关键词：
LTP; SYNAPTIC PLASTICITY; NMDA RECEPTOR; CA2+; CA2+ POOL; HIPPOCAMPUS;
D O I：
10.1016/0304-3940(92)90551-H
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Experiments were performed to investigate whether intact intracellular Ca2+ pools are necessary for long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Thapsigargin (1-mu-M), which depletes most intracellular Ca2+ pools by blocking ATP-dependent Ca2+ uptake into intracellular compartments, blocked the induction but not the expression of LTP. Thapsigargin had no effect on synaptic transmission or on responses mediated by N-methyl-D-aspartate (NMDA) receptor activation. These data suggest that Ca2+ release from intracellular stores is required for the induction of LTP.
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页码：197 / 200
页数：4
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