TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF INTERLEUKIN-1 GENE-EXPRESSION - REVIEW

被引：105

作者：

FENTON, MJ ^{[1
]}

机构：

[1] BOSTON UNIV, MED CTR, EVANS DEPT CLIN RES, BOSTON, MA 02118 USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 03期

关键词：

D O I：

10.1016/0192-0561(92)90170-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 1-alpha (IL-1-alpha) and beta (IL-1-beta) are proinflammatory cytokines that are encoded by distinct genes, but share most biological activities. During the past several years, intense investigation has focused on elucidating the molecular basis for the regulation of IL-1-alpha and beta-gene expression. While the overall organization of both genes is conserved in mammals, the DNA sequence homology is surprisingly limited. This supports the growing body of evidence suggesting that each gene is regulated by distinct cis- and trans-acting elements. Most recently, novel regulatory DNA sequence elements and several nuclear regulatory proteins have been identified, which ultimately participate in the control of IL-1-beta-gene transcription. In addition to transcriptional controls, the stability of IL-1 mRNA can be selectively regulated by various inducing stimuli and other cytokines. Taken together, these transcriptional and post-transcriptional regulatory mechanisms provide stringent, yet flexible, control over expression of the IL-1-alpha and beta-genes.

引用

页码：401 / 411

页数：11

共 94 条

[11]

BURCHETT SK, 1988, J IMMUNOL, V140, P3473

[12] IDENTIFICATION OF A COMMON NUCLEOTIDE-SEQUENCE IN THE 3'-UNTRANSLATED REGION OF MESSENGER-RNA MOLECULES SPECIFYING INFLAMMATORY MEDIATORS [J].

CAPUT, D ;

BEUTLER, B ;

HARTOG, K ;

THAYER, R ;

BROWNSHIMER, S ;

CERAMI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) :1670-1674

[13] 2 HIGH-AFFINITY INTERLEUKIN-1 RECEPTORS REPRESENT SEPARATE GENE-PRODUCTS [J].

CHIZZONITE, R ;

TRUITT, T ;

KILIAN, PL ;

STERN, AS ;

NUNES, P ;

PARKER, KP ;

KAFFKA, KL ;

CHUA, AO ;

LUGG, DK ;

GUBLER, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :8029-8033

[14] GENOMIC SEQUENCE FOR HUMAN PROINTERLEUKIN-1-BETA - POSSIBLE EVOLUTION FROM A REVERSE TRANSCRIBED PROINTERLEUKIN-1-ALPHA GENE [J].

CLARK, BD ;

COLLINS, KL ;

GANDY, MS ;

WEBB, AC ;

AURON, PE .

NUCLEIC ACIDS RESEARCH, 1986, 14 (20) :7897-7914

[15]

CLARK BD, 1988, MONOKINES OTHER NONL, P47

[16] GAMMA-INTERFERON ENHANCES MACROPHAGE TRANSCRIPTION OF THE TUMOR-NECROSIS-FACTOR CACHECTIN, INTERLEUKIN-1, AND UROKINASE GENES, WHICH ARE CONTROLLED BY SHORT-LIVED REPRESSORS [J].

COLLART, MA ;

BELIN, D ;

VASSALLI, JD ;

DEKOSSODO, S ;

VASSALLI, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (06) :2113-2118

[17] INDUCTION OF CELL-ASSOCIATED INTERLEUKIN-1 THROUGH STIMULATION OF THE ADHESION-PROMOTING PROTEINS LFA-1 (CD11A/CD18) AND CR3 (CD11B/CD18) OF HUMAN MONOCYTES [J].

COUTURIER, C ;

HAEFFNERCAVAILLON, N ;

WEISS, L ;

FISCHER, E ;

KAZATCHKINE, MD .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (05) :999-1005

[18] FOS AND JUN - THE AP-1 CONNECTION [J].

CURRAN, T ;

FRANZA, BR .

CELL, 1988, 55 (03) :395-397

[19] EXPRESSION OF RAS ONCOGENES IN CULTURED HUMAN-CELLS ALTERS THE TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF CYTOKINE GENES [J].

DEMETRI, GD ;

ERNST, TJ ;

PRATT, ES ;

ZENZIE, BW ;

RHEINWALD, JG ;

GRIFFIN, JD .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (04) :1261-1269

[20] INTERLEUKIN-1-ALPHA AND BETA-GENES - LINKAGE ON CHROMOSOME-2 IN THE MOUSE [J].

DEUSTACHIO, P ;

JADIDI, S ;

FUHLBRIGGE, RC ;

GRAY, PW ;

CHAPLIN, DD .

IMMUNOGENETICS, 1987, 26 (06) :339-343

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