MULTIPLE-SCLEROSIS - AN AUTOIMMUNE-DISEASE OF MULTIFACTORIAL ETIOLOGY

被引：81
作者：
BERNARD, CCA
DEROSBO, NK
机构：
[1] La Trobe University, Buncloora, Vic.
来源：
CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 06期
关键词：
D O I：
10.1016/0952-7915(92)90058-M
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The etiology of multiple sclerosis is linked to a variety of genetic and environmental factors. Both cell-mediated and humoral immune responses, triggered by extraneous or autoantigens, are likely to contribute to the pathogenesis of this disease. A greater insight into the fundamental cause of multiple sclerosis has been provided by the recognition that certain immune response genes are associated with an increased susceptibility to the disease. Such knowledge should provide new opportunities for selective therapeutic interventions.
引用
收藏
页码：760 / 765
页数：6
相关论文
共 60 条
  • [1] LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION
    ACHAORBEA, H
    MITCHELL, DJ
    TIMMERMANN, L
    WRAITH, DC
    TAUSCH, GS
    WALDOR, MK
    ZAMVIL, SS
    MCDEVITT, HO
    STEINMAN, L
    [J]. CELL, 1988, 54 (02) : 263 - 273
  • [2] PURIFICATION AND PARTIAL STRUCTURAL AND FUNCTIONAL-CHARACTERIZATION OF MOUSE MYELIN OLIGODENDROCYTE GLYCOPROTEIN
    AMIGUET, P
    GARDINIER, MV
    ZANETTA, JP
    MATTHIEU, JM
    [J]. JOURNAL OF NEUROCHEMISTRY, 1992, 58 (05) : 1676 - 1682
  • [3] THE GERMLINE REPERTOIRE OF T-CELL RECEPTOR BETA-CHAIN GENES IN PATIENTS WITH CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS
    BEALL, SS
    CONCANNON, P
    CHARMLEY, P
    MCFARLAND, HF
    GATTI, RA
    HOOD, LE
    MCFARLIN, DE
    BIDDISON, WE
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1989, 21 (01) : 59 - 66
  • [4] HLA-DP-BETA AND SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS - AN ANALYSIS OF CAUCASOID AND JAPANESE PATIENT POPULATIONS
    BEGOVICH, AB
    HELMUTH, RC
    OKSENBERG, JR
    SAKAI, K
    TABIRA, T
    SASAZUKI, T
    STEINMAN, L
    ERLICH, HA
    [J]. HUMAN IMMUNOLOGY, 1990, 28 (04) : 365 - 372
  • [5] BENNUN A, 1991, P NATL ACAD SCI USA, V88, P2466, DOI 10.1073/pnas.88.6.2466
  • [6] BERNARD CCA, 1992, AUTOIMMUNE DISEASES, V2, P47
  • [7] BERNARD CCA, 1991, ACTA NEUROL, V13, P170
  • [8] T-CELL RECEPTORS, IMMUNOREGULATION, AND AUTOIMMUNITY
    BROSTOFF, SW
    HOWELL, MD
    [J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1992, 62 (01): : 1 - 7
  • [9] DIFFERENTIAL ULTRASTRUCTURAL-LOCALIZATION OF MYELIN BASIC-PROTEIN, MYELIN OLIGODENDROGLIAL GLYCOPROTEIN, AND 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE IN THE CNS OF ADULT-RATS
    BRUNNER, C
    LASSMANN, H
    WAEHNELDT, TV
    MATTHIEU, JM
    LININGTON, C
    [J]. JOURNAL OF NEUROCHEMISTRY, 1989, 52 (01) : 296 - 304
  • [10] BOTH RAT AND MOUSE T-CELL RECEPTORS SPECIFIC FOR THE ENCEPHALITOGENIC DETERMINANT OF MYELIN BASIC-PROTEIN USE SIMILAR V-ALPHA AND V-BETA CHAIN GENES EVEN THOUGH THE MAJOR HISTOCOMPATIBILITY COMPLEX AND ENCEPHALITOGENIC DETERMINANTS BEING RECOGNIZED ARE DIFFERENT
    BURNS, FR
    LI, XO
    SHEN, N
    OFFNER, H
    CHOU, YK
    VANDENBARK, AA
    HEBERKATZ, E
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) : 27 - 39
123456