A THEORETICAL STUDY OF ELECTROSTATIC INTERACTIONS IN INTERCALATION MODEL OF DNA-DYE COMPLEX

被引:20
作者
GILBERT, M
CLAVERIE, P
机构
[1] Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique, Paris Ve
关键词
D O I
10.1016/0022-5193(68)90082-9
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The role played by the electrostatic interactions in the intercalation model of the DNA-aminoacridine complex is investigated. Two problems are considered: the existence of a maximum degree of association and the dependence of aminoacridine binding on the ionic strength. The intercalation model is shown to be compatible with a number of experimental data concerning the strong binding of aminoacridines to native DNA. © 1968.
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页码:330 / &
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