Tumour-infiltrating CD4 and CD8 T lymphocytes in breast cancer

被引：5

作者：

Gisterek, Iwona ^{[1
]}

Frydecka, Irena ^{[1
]}

Swiatoniowski, Grzegorz ^{[1
]}

Fidler, Sebastian ^{[1
]}

Kornafel, Jan ^{[1
]}

机构：

[1] Med Univ Wroclaw, Dept Oncol, PL-53413 Wroclaw, Poland

来源：

REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY | 2008年 / 13卷 / 04期

关键词：

breast cancer; CD4(+); CD8(+);

D O I：

10.1016/S1507-1367(10)60011-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphocytes are cells circulating between the blood and tissues. It has been stated that a correlation exists between immune infiltrate and breast cancer. These tumours are infiltrated by T cells, B cells, natural killer cells and macrophages. The infiltrating T cells are of helper (CD4(+)) and cytotoxic (CD8(+)) phenotypes. Specific immunity mediated by cytolytic T lymphocytes is suspected of playing an anticancer role. It is widely known that regional lymph nodes are an important immunological defence or "barrier" against tumour expansion. Some authors have reported that in cancer patients natural killer (NK) cells and CD8(+) T cells are diminished in regional lymph nodes, particularly those involved by the tumour. In the presented study the authors review current knowledge on this problem and the possibility of using successful immunotherapy with monoclonal antibodies for breast cancer.

引用

页码：206 / 209

页数：4

共 30 条

[21]

2-X

[22] THE CONTRIBUTION OF REGIONAL LYMPH-NODES IN THE RESISTANCE AGAINST BREAST-CANCER - PRACTICAL IMPLICATIONS [J].

PAPAIOANNOU, A .

JOURNAL OF SURGICAL ONCOLOGY, 1984, 25 (04) :232-239

[23] Major histocompatibility complex status in breast carcinogenesis and relationship to apoptosis [J].

Redondo, M ;

García, J ;

Villar, E ;

Rodrigo, I ;

Perea-Milla, E ;

Serrano, A ;

Morell, M .

HUMAN PATHOLOGY, 2003, 34 (12) :1283-1289

[24] FUNCTIONAL-CHARACTERIZATION OF TUMOR-INFILTRATING LYMPHOCYTES, LYMPH-NODE LYMPHOCYTES AND PERIPHERAL-BLOOD LYMPHOCYTES FROM PATIENTS WITH BREAST-CANCER [J].

RUBBERT, A ;

MANGER, B ;

LANG, N ;

KALDEN, JR ;

PLATZER, E .

INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (01) :25-31

[25] Immunohistochemical evaluation of immune response in invasive ductal breast cancer of not-otherwise-specified type [J].

Vgenopoulou, S ;

Lazaris, AC ;

Markopoulos, C ;

Boltetsou, E ;

Kyriakou, V ;

Kavantzas, N ;

Patsouris, E ;

Davaris, PS .

BREAST, 2003, 12 (03) :172-178

[26] Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple mRNA markers [J].

Weigelt, B ;

Verduijn, P ;

Bosma, AJ ;

Rutgers, EJ ;

Peterse, HL ;

van't Veer, LJ .

BRITISH JOURNAL OF CANCER, 2004, 90 (08) :1531-1537

[27] LYMPHOCYTE SUBSETS IN THE BLOOD - A DIAGNOSTIC WINDOW ON THE LYMPHOID SYSTEM [J].

WESTERMANN, J ;

PABST, R .

IMMUNOLOGY TODAY, 1990, 11 (11) :406-410

[28]

WHITFORD P, 1992, EUR J CANCER, V28A, P350, DOI 10.1016/S0959-8049(05)80052-8

[29] FLOW CYTOMETRIC ANALYSIS OF TUMOR INFILTRATING LYMPHOCYTES IN BREAST-CANCER [J].

WHITFORD, P ;

MALLON, EA ;

GEORGE, WD ;

CAMPBELL, AM .

BRITISH JOURNAL OF CANCER, 1990, 62 (06) :971-975

[30] Functional analysis of tumor-infiltrating leukocytes in breast cancer patients [J].

Wong, PY ;

Staren, ED ;

Tereshkova, N ;

Braun, DP .

JOURNAL OF SURGICAL RESEARCH, 1998, 76 (01) :95-103

← 1 2 3 →