PLASMA-LEVELS OF THE CHEMOKINES MONOCYTE CHEMOTACTIC PROTEIN-1 AND PROTEIN-2 ARE ELEVATED IN HUMAN SEPSIS

被引:148
作者
BOSSINK, AWJ
PAEMEN, L
JANSEN, PM
HACK, CE
THIJS, LG
VANDAMME, J
机构
[1] UNIV LOUVAIN,REGA INST MED RES,LOUVAIN,BELGIUM
[2] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,AMSTERDAM,NETHERLANDS
[3] UNIV AMSTERDAM,CLIN & EXPTL IMMUNOL LAB,AMSTERDAM,NETHERLANDS
关键词
D O I
10.1182/blood.V86.10.3841.bloodjournal86103841
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Because of their effects on monocytes, monocyte chemotactic proteins-1 and -2 (MCP-1 and MCP-2) may participate in the pathophysiology of sepsis. We measured circulating MCP-1 and MCP-2 levels in 42 septic patients having positive local or blood cultures. MCP-1 and MCP-2 levels were elevated in 24 (57%) and 25 (59%) of 42 septic patients, respectively, compared with healthy volunteers. Both patients with gram-positive and gram-negative infections had elevated MCP-1 plasma levels (P = .0001 and P < .0001, respectively; Mann Whitney-U test), whereas patients with gram-positive infection, but not those with gram-negative infection, had increased MCP-2 plasma levels (P = .0182). No relative differences in MCP-1 and MCP-2 plasma levels were observed between several subgroups of patients (sepsis v septic shock; survivors v nonsurvivors), although levels of MCP-1 were the highest in patients with the more severe forms of sepsis, ie, those with shock or a lethal outcome. Serial observations showed that MCP-1 and MCP-2 plasma levels remained elevated for at least 48 hours. MCP-1 correlated weakly with interleukin-8 and MCP-2, the correlations for which were most pronounced in patients with septic shock. MCP-2 correlated with interleukin-8 and, surprisingly, with the complement activation product C3a; these correlations further improved when analyzing patients with septic shock or when analyzing gram-positive infections. Thus, our results not only show increased MCP-1 and MCP-2 levels in patients with sepsis, but also suggest that the synthesis and release of MCP-1 and MCP-2 in sepsis are differently regulated in part. (C) by 1995 by The American Society of Hematology.
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页码:3841 / 3847
页数:7
相关论文
共 34 条
[1]  
[Anonymous], 1992, CRIT CARE MED, V20, P864
[2]   NEUTROPHIL-ACTIVATING PEPTIDE-1 INTERLEUKIN-8, A NOVEL CYTOKINE THAT ACTIVATES NEUTROPHILS [J].
BAGGIOLINI, M ;
WALZ, A ;
KUNKEL, SL .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (04) :1045-1049
[3]   CYTOKINES AND THEIR INTERACTIONS WITH OTHER INFLAMMATORY MEDIATORS IN THE PATHOGENESIS OF SEPSIS AND SEPTIC SHOCK [J].
BILLIAU, A ;
VANDEKERCKHOVE, F .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1991, 21 (06) :559-573
[4]   ELEVATED IL-8 AND MCP-1 IN THE BRONCHOALVEOLAR LAVAGE FLUID OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS AND PULMONARY SARCOIDOSIS [J].
CAR, BD ;
MELONI, F ;
LUISETTI, M ;
SEMENZATO, G ;
GIALDRONIGRASSI, G ;
WALZ, A .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (03) :655-659
[5]   THE ROLE OF CACHECTIN/TNF IN ENDOTOXIC-SHOCK AND CACHEXIA [J].
CERAMI, A ;
BEUTLER, B .
IMMUNOLOGY TODAY, 1988, 9 (01) :28-31
[6]  
DINARELLO CA, 1991, BLOOD, V77, P1627
[7]   ELEVATED PLASMA-LEVELS OF THE ANAPHYLATOXINS C3A AND C4A ARE ASSOCIATED WITH A FATAL OUTCOME IN SEPSIS [J].
HACK, CE ;
NUIJENS, JH ;
FELTBERSMA, RJF ;
SCHREUDER, WO ;
EERENBERGBELMER, AJM ;
PAARDEKOOPER, J ;
BRONSVELD, W ;
THIJS, LG .
AMERICAN JOURNAL OF MEDICINE, 1989, 86 (01) :20-26
[8]  
HACK CE, 1989, BLOOD, V74, P1704
[9]   A MODEL FOR THE INTERPLAY OF INFLAMMATORY MEDIATORS IN SEPSIS - A STUDY IN 48 PATIENTS [J].
HACK, CE ;
NUIJENS, JH ;
VANSCHIJNDEL, RJMS ;
ABBINK, JJ ;
EERENBERG, AJM ;
THIJS, LG .
INTENSIVE CARE MEDICINE, 1990, 16 :S187-S191
[10]   INTERLEUKIN-8 IN SEPSIS - RELATION TO SHOCK AND INFLAMMATORY MEDIATORS [J].
HACK, CE ;
HART, M ;
VANSCHIJNDEL, RJMS ;
EERENBERG, AJM ;
NUIJENS, JH ;
THIJS, LG ;
AARDEN, LA .
INFECTION AND IMMUNITY, 1992, 60 (07) :2835-2842