SEPARATE REGULATION OF HEME OXYGENASE AND HEAT-SHOCK PROTEIN-70 MESSENGER-RNA EXPRESSION IN THE RAT-HEART BY HEMODYNAMIC STRESS

被引：54
作者：
KATAYOSE, D
ISOYAMA, S
FUJITA, H
SHIBAHARA, S
机构：
[1] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1,1-1 SEIRYO MACHI,AOBA KU,SENDAI,MIYAGI 980,JAPAN
[2] TOHOKU UNIV,SCH MED,DEPT APPL PHYSIOL & MOLEC BIOL,SENDAI,MIYAGI 980,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 02期
关键词：
D O I：
10.1006/bbrc.1993.1258
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To elucidate the role of heat shock proteins in hearts, we examined the expression of heme oxygenase (HO) and heat shock protein 70 (HSP70) mRNAs in hearts of rats subjected to hypoxia or pulmonary artery banding, both of which produce pressure overload to the right ventricle. At 3 d of hypoxia, HO mRNA levels were elevated about fourfold compared to the basal levels in both right and left ventricles, while HSP70 mRNA s was not induced at all. Pulmonary artery banding markedly and immediately (within 6 h) increased HO mRNA levels in both ventricles, but induced HSP70 mRNA only in the right ventricle. This is the first in vivo evidence showing the separate regulation of HO and HSP70 gene expression in hearts by hemodynamic stress. © 1993 Academic Press.
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页码：587 / 594
页数：8
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