A NOVEL ROLE FOR DOPAMINE - INHIBITION OF MUSCARINIC CHOLINERGIC-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN RAT-BRAIN CORTICAL MEMBRANES

被引：23

作者：

WALLACE, MA

CLARO, E

机构：

[1] University of Tennessee, Memphis, Department of Biochemistry, Memphis

来源：

NEUROSCIENCE LETTERS | 1990年 / 110卷 / 1-2期

关键词：

Brain cortex; Carbachol; Dopamine; Muscarinic; Phosphoinositide; Phospholipase C;

D O I：

10.1016/0304-3940(90)90804-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dopamine inhibited phosphoinositide breakdown as stimulated by carbachol in rat brain cortical membranes. The IC50 value was 14 ± 2 μM for dopamine's inhibition of phosphatidylinositol hydrolysis as stimulated by 1 mM carbachol. The inhibition was found at low (0.1 μM), but not high (> 0.3 μM), concentrations of the non-hydrolyzable guanine nucleotide analog, GTPγS. Pharmacological characterization of the response indicated that the dopamine effects were mediated by D1 receptors. The assay conditions precluded any involvement of cyclic-AMP as a mediator of the dopamine response, and thus, a novel role is proposed for dopamine in cortex working through D1 receptors to inhibit phosphoinositide degradation. © 1990.

引用

页码：155 / 161

页数：7

共 21 条

[11]

Fuxe K, 1988, Adv Exp Med Biol, V235, P83

[12]

JOURNOT L, 1987, J BIOL CHEM, V262, P15106

[13] MULTIPLE RECEPTORS FOR DOPAMINE [J].