Interrater Reliability of the Unified Huntington's Disease Rating Scale-Total Motor Score Certification

被引:15
作者
Winder, Jessica Y. [1 ]
Roos, Raymund A. C. [1 ]
Burgunder, Jean-Marc [2 ,3 ]
Marinus, Johan [1 ]
Reilmann, Ralf [4 ,5 ,6 ,7 ]
机构
[1] Leiden Univ, Dept Neurol, Med Ctr, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands
[2] Univ Bern, Dept Neurol, Bern, Switzerland
[3] Swiss Huntington Ctr, Gumlingen, Switzerland
[4] George Huntington Inst, Munster, Germany
[5] Univ Munster, Dept Radiol, Munster, Germany
[6] Univ Tubingen, Dept Neurodegenerat Dis, Tubingen, Germany
[7] Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany
关键词
annual online certification; Huntington's disease; interrater reliability; Unified Huntington's Disease Rating Scale-Total Motor Score;
D O I
10.1002/mdc3.12618
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BackgroundThe clinical assessment of motor symptoms in Huntington's disease is usually performed with the Unified Huntington's Disease Rating Scale-Total Motor Score (UHDRS-TMS). A high interrater reliability is desirable to monitor symptom progression. Therefore, a teaching video and a system for annual online certification has been developed and implemented. ObjectivesThe aim of this study is to investigate the interrater reliability of the UHDRS-TMS and of its subitems, and to examine the performance of raters in consecutive years. MethodsData from the online UHDRS-TMS certification were used. The interrater reliability was assessed for all first-time participants (n = 944) between 2009 and 2016. Intraclass correlation coefficients (ICC) were calculated for each year separately and the mean was taken as the total ICC. ResultsThe UHDRS-TMS (ICC = 0.847), tandem walking (0.824), pronate/supinate hands left (0.713), and retropulsion pull test (0.706) showed good interrater reliability. Poor interrater reliability was found for maximal dystonia of the left and right upper extremity (0.187 and 0.322, respectively), maximal dystonia of the left and right lower extremity (0.200 and 0.256, respectively), and maximal dystonia of the trunk (0.389), tongue protrusion (0.266), and rigidity arms left (0.390). Raters performed significantly worse on follow-up certification compared to their first certification. ConclusionsOur results suggest that the rating of dystonia (absent, slight, mild, moderate, or marked) is subjective and difficult to interpret, especially on video. Therefore, changing the dystonia items of the UHDRS-TMS should be explored. We also recommend that raters should watch the UHDRS-TMS teaching video before each certification.
引用
收藏
页码:290 / 295
页数:6
相关论文
共 16 条
[1]  
Cicchetti D.V., 1994, PSYCHOL ASSESSMENT, V6, P284, DOI [10.1037/1040-3590.6.4.284, DOI 10.1037/1040-3590.6.4.284]
[2]   FUNCTIONAL DECLINE IN HUNTINGTONS-DISEASE [J].
FEIGIN, A ;
KIEBURTZ, K ;
BORDWELL, K ;
COMO, P ;
STEINBERG, K ;
SOTACK, J ;
ZIMMERMAN, C ;
HICKEY, C ;
ORME, C ;
SHOULSON, I .
MOVEMENT DISORDERS, 1995, 10 (02) :211-214
[3]   Unified Huntington's disease rating scale: Reliability and consistency [J].
Kieburtz, K ;
Penney, JB ;
Como, P ;
Ranen, N ;
Shoulson, I ;
Feigin, A ;
Abwender, D ;
Greenamyre, JT ;
Higgins, D ;
Marshall, FJ ;
Goldstein, J ;
Steinberg, K ;
Shih, C ;
Richard, I ;
Hickey, C ;
Zimmerman, C ;
Orme, C ;
Claude, K ;
Oakes, D ;
Sax, DS ;
Kim, A ;
Hersch, S ;
Jones, R ;
Auchus, A ;
Olsen, D ;
BisseyBlack, C ;
Rubin, A ;
Schwartz, R ;
Dubinsky, R ;
Mallonee, W ;
Gray, C ;
Godfrey, N ;
Suter, G ;
Shannon, KM ;
Stebbins, GT ;
Jaglin, JA ;
Marder, K ;
Taylor, S ;
Louis, E ;
Moskowitz, C ;
Thorne, D ;
Zubin, N ;
Wexler, N ;
Swenson, MR ;
Paulsen, J ;
Swerdlow, N ;
Albin, R ;
Wernette, C ;
Walker, F ;
Hunt, V .
MOVEMENT DISORDERS, 1996, 11 (02) :136-142
[4]   Dystonia-predominant adult-onset Huntington disease -: Association between motor phenotype and age of onset in adults [J].
Louis, ED ;
Anderson, KE ;
Moskowitz, C ;
Thorne, DZ ;
Marder, K .
ARCHIVES OF NEUROLOGY, 2000, 57 (09) :1326-1330
[5]   A NOVEL GENE CONTAINING A TRINUCLEOTIDE REPEAT THAT IS EXPANDED AND UNSTABLE ON HUNTINGTONS-DISEASE CHROMOSOMES [J].
MACDONALD, ME ;
AMBROSE, CM ;
DUYAO, MP ;
MYERS, RH ;
LIN, C ;
SRINIDHI, L ;
BARNES, G ;
TAYLOR, SA ;
JAMES, M ;
GROOT, N ;
MACFARLANE, H ;
JENKINS, B ;
ANDERSON, MA ;
WEXLER, NS ;
GUSELLA, JF ;
BATES, GP ;
BAXENDALE, S ;
HUMMERICH, H ;
KIRBY, S ;
NORTH, M ;
YOUNGMAN, S ;
MOTT, R ;
ZEHETNER, G ;
SEDLACEK, Z ;
POUSTKA, A ;
FRISCHAUF, AM ;
LEHRACH, H ;
BUCKLER, AJ ;
CHURCH, D ;
DOUCETTESTAMM, L ;
ODONOVAN, MC ;
RIBARAMIREZ, L ;
SHAH, M ;
STANTON, VP ;
STROBEL, SA ;
DRATHS, KM ;
WALES, JL ;
DERVAN, P ;
HOUSMAN, DE ;
ALTHERR, M ;
SHIANG, R ;
THOMPSON, L ;
FIELDER, T ;
WASMUTH, JJ ;
TAGLE, D ;
VALDES, J ;
ELMER, L ;
ALLARD, M ;
CASTILLA, L ;
SWAROOP, M .
CELL, 1993, 72 (06) :971-983
[6]   Rate of functional decline in Huntington's disease [J].
Marder, K ;
Zhao, H ;
Myers, RH ;
Cudkowicz, M ;
Kayson, E ;
Kieburtz, K ;
Orme, C ;
Paulsen, J ;
Penney, JB ;
Siemers, E ;
Shoulson, I .
NEUROLOGY, 2000, 54 (02) :452-458
[7]   Rate of Change in Early Huntington's Disease: a Clinicometric Analysis [J].
Meyer, Christina ;
Landwehrmeyer, Bernhard ;
Schwenke, Carsten ;
Doble, Adam ;
Orth, Michael ;
Ludolph, Albert C. .
MOVEMENT DISORDERS, 2012, 27 (01) :118-124
[8]  
Nunnally J.C., 1994, PSYCHOMETRIC THEORY, DOI DOI 10.1037/018882
[9]  
Reilmann R., 2009, AKTUELLE NEUROL, V36, pP474, DOI DOI 10.1055/S-0029-1238568
[10]  
Reilmann R, 2017, HAND CLINIC, V144, P209, DOI 10.1016/B978-0-12-801893-4.00018-3