Obtaining New Biologically Active Compounds from 2-Vinyloxyethylisothiocyanate

Via the reaction of alkaloid cytisine, l-ephedrine, d-pseudoephedrine as well as glucosylbenzylamine and xylosylbenzylamine aminoglycosides with vinyloxyethylisothiocyanate and its acetal derivatives, we synthesized and characterized novel 2-vinyl-, N-1-propargyl-, 1-N-phenyloxyethoxyethylo-N'-aminothiourea species. By the example of the N-vinylethoxythiocarbamoyl derivatives of l-ephedrine and d-pseudoephedrine is demonstrated that the mentioned thiourea species could quite readily undergo hydrolyzing in the presence of acids. On the basis of salicylic acid hydrazide we have synthesized and studied the acidic hydrolysis of corresponding vinyloxyethylthiosemicarbazide. The composition and the structure of the thiourea derivatives synthesized were confirmed by IR spectroscopy, H-1 NMR, C-13 NMR and mass spectrometry as well as by XRD structural analysis.