GENETIC-HETEROGENEITY OF FAMILIAL HEMIPLEGIC MIGRAINE

被引:121
作者
OPHOFF, RA
VANEIJK, R
SANDKUIJL, LA
TERWINDT, GM
GRUBBEN, CPM
HAAN, J
LINDHOUT, D
FERRARI, MD
FRANTS, RR
机构
[1] LEIDEN STATE UNIV,MGC,DEPT HUMAN GENET,SYLVIUS LAB,2333 AL LEIDEN,NETHERLANDS
[2] LEIDEN UNIV,DEPT NEUROL,LEIDEN,NETHERLANDS
[3] RIJNLAND HOSP,DEPT NEUROL,LEIDERDORP,NETHERLANDS
[4] ERASMUS UNIV ROTTERDAM,MGC,DEPT CLIN GENET,3000 DR ROTTERDAM,NETHERLANDS
关键词
D O I
10.1006/geno.1994.1340
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migraine-like attacks are associated with transient hemiparesis. A locus for FHM has recently been assigned to chromosome 19 by linkage mapping. In the present study, five unrelated pedigrees with multiple members suffering from hemiplegic migraine were investigated. In two of the pedigrees additional symptoms, cerebellar ataxia and benign neonatal convulsions, respectively, were observed in affected members. Three pedigrees showed linkage to loci D19S391, D19S221, and D19S226 at chromosome 19p13. Haplotyping suggested a location of a FHM gene between D19S391 and D19S221. In the two remaining families, evidence against linkage was found. These results confirm the localization of a gene for familial hemiplegic migraine to the short arm of chromosome 19, but locus heterogeneity not corresponding to the observed clinical heterogeneity is likely to exist. (C) 1994 Academic Press, Inc.
引用
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页码:21 / 26
页数:6
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