CLASSIFICATION OF HUMAN BRAIN PARTS USING PATTERN-RECOGNITION BASED ON INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROSCOPY AND INSTRUMENTAL NEUTRON-ACTIVATION ANALYSIS

被引：6

作者：

ANDRASI, E

VARGA, I

DOZSA, A

REFFY, A

NAGY, GJ

机构：

[1] NATL INST TRAUMATOL, H-1081 BUDAPEST, HUNGARY

[2] EOTVOS LORAND UNIV, DEPT CHEM CYBERNET, H-1518 BUDAPEST 112, HUNGARY

来源：

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS | 1994年 / 22卷 / 01期

关键词：

D O I：

10.1016/0169-7439(93)E0048-9

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This project aims at investigating possible trace element changes in histopathologically selected brain regions of patients with Alzheimer's disease (six individuals, ten brain parts). Determinations were carried out by inductively coupled plasma atomic emission spectrometry and instrumental neutron activation analysis. The main (Na, K, Mg, Ca, Fe, P, S) and trace (Al, B, Ba, Co, Cr, Cu, Mn, Ni, Pb, Sr and Zn) elements were investigated. Quality control was ensured by using Bovine Liver standard reference materials from the National Bureau of Standards. The results were graphically illustrated by means of cluster analysis dendrograms where classification of the subjects is effected by placing them into homogeneous groups in a way that any relation between the groups is revealed. Our preliminary results indicate a possible correlation of the brain Al and Zn concentrations (and the Sr, Ba, Cu contents in some brain parts) with Alzheimer's disease.

引用

页码：107 / 114

页数：8

共 21 条

[1] DETERMINATION OF MAIN AND TRACE-ELEMENT CONTENTS IN HUMAN BRAIN BY NAA AND ICP-AES METHODS [J].