ESR MEASUREMENTS AND THE DETECTION OF RADIOSTERILIZATION OF DRUGS

被引：34

作者：

GIBELLA, M ^{[1
]}

CRUCQ, AS ^{[1
]}

TILQUIN, B ^{[1
]}

机构：

[1] ECOLE PHARM UCL,UNITE CHAM,7230 AV E MOUNIER,B-1200 WOLUWE ST LAMBERT,BELGIUM

来源：

JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1993年 / 90卷 / 04期

关键词：

D O I：

10.1051/jcp/1993901041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ESR spectrum of trapped radicals in irradiated solid antibiotics could permit the detection of the radiosterilization. The ESR signal is detected only after radiolysis; at room temperature, this ESR spectrum is observable for a few hours or until several years. The rate of the metathesis reactions can be fast or very slow, the reaction path is unknown. However, in many cases, the polycrystalline solid phase exhibits its ability to keep radicals for a long period of time and the detection of the radiolysis is possible during this period.

引用

页码：1041 / 1053

页数：13