Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma lucidum

被引：38
作者：
Bhardwaj, Neha [1 ]
Katyal, Priya [2 ]
Sharma, Anil K. [1 ]
机构：
[1] Maharishi Markandeshwar Univ, Dept Biotechnol, Mullana Ambala 133207, Haryana, India
[2] Punjab Agr Univ, Dept Microbiol, Ludhiana 141004, Punjab, India
来源：
RECENT PATENTS ON INFLAMMATION & ALLERGY DRUG DISCOVERY | 2014年 / 8卷 / 02期
关键词：
Anti-allergic; anti-inflammatory; formulations; Ganoderma lucidum; immune-modulating; inflammation;
D O I：
10.2174/1872213X08666140619110657
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Acute inflammation is the result of a complex signal transduction pathway that protects and heals our body and is necessary for our good health and normal wellbeing. Whereas, chronic inflammation can be correlated well with the onset of a plethora of autoimmune disorders; rheumatoid arthritis, systemic lupus and polymyalgia, rheumatic and other diseases like asthma, inflammatory bowel diseases, cardiovascular disorders, ulcerative colitis and Crohn's disease. Also, it has been reported to be associated with the onset of various cancers. An effective anti-inflammatory drug should be able to inhibit the development of chronic inflammation without interfering in normal homeostasis. A number of herbal drugs have been identified in the past that can target inflammatory cytokines. Among these, Ganoderma lucidum: a powerful medicinal mushroom has been found to possess immune-modulating and immune-potentiating capabilities and has been characterized as a wonder herb. This review mainly focuses on the molecular mechanism of anti-inflammatory and anti-allergic action of this mushroom and also sheds light on various patent studies related to its pharmacological action.
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页码：104 / 117
页数：14
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