COMPATIBILITY STUDY BETWEEN NAPROXEN AND TABLET EXCIPIENTS USING DIFFERENTIAL SCANNING CALORIMETRY

被引：51
|
作者：
BOTHA, SA
LOTTER, AP
机构：
[1] Research Institute for Industrial Pharmacy Potchefstroom University for C.H.E., Potchefstroom
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 04期
关键词：
D O I：
10.3109/03639049009104410
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Differential scanning calorimetry (DSC) was used to investigate the physico-chemical compatibility between naproxen and a number of commonly used tablet excipients. Interactions of naproxen with PVP, cross-linked PVP, Emcompress and the lubricants stearic acid, magnesium stearate and Precirol Ato 5 were found. Naproxen was found to be compatible with starch, Sta-Rx 1500, Primojel, Explotab, Avicel PH 101, Elcema G250, Ac-Di-Sol and Sterotex. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：673 / 683
页数：11
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