DESIGN AND SYNTHESIS OF BIOCOMPATIBLE POLYMERIC MATERIALS

被引：20

作者：

IMANISHI, Y

ITO, Y

LIU, LS

KAJIHARA, M

机构：

[1] Kyoto Univ, Japan

来源：

JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY | 1988年 / A25卷 / 5-7期

关键词：

Biomaterials--Synthesis - Enzymes--Immobilization - Proteins - Silicones--Thin Films;

D O I：

10.1080/00222338808053384

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

One approach to antithrombogenic materials, the combination of synthetic polymers with physiologically active substances, seems to be promising. This involves crosslinked urokinase (HM-UK), in which urokinases are linked with side chains of poly(2-hydroxyethyl methacrylate)(PHEMA) by 4,4′-diisocyanatodiphenyl-methane, and encapsulated urokinase (HMe-UK), in which urokinases are encapsulated in the network of crosslinked PHEMA. The HMe-UK with a low degree of crosslinking was found to be highly antithrombogenic.

引用

页码：555 / 570

页数：16

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