DESIGN AND SYNTHESIS OF BIOCOMPATIBLE POLYMERIC MATERIALS

被引：20
|
作者：
IMANISHI, Y
ITO, Y
LIU, LS
KAJIHARA, M
机构：
[1] Kyoto Univ, Japan
来源：
JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY | 1988年 / A25卷 / 5-7期
关键词：
Biomaterials--Synthesis - Enzymes--Immobilization - Proteins - Silicones--Thin Films;
D O I：
10.1080/00222338808053384
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
One approach to antithrombogenic materials, the combination of synthetic polymers with physiologically active substances, seems to be promising. This involves crosslinked urokinase (HM-UK), in which urokinases are linked with side chains of poly(2-hydroxyethyl methacrylate)(PHEMA) by 4,4′-diisocyanatodiphenyl-methane, and encapsulated urokinase (HMe-UK), in which urokinases are encapsulated in the network of crosslinked PHEMA. The HMe-UK with a low degree of crosslinking was found to be highly antithrombogenic.
引用
收藏
页码：555 / 570
页数：16
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