ON THE ROLE OF NMDA RECEPTORS IN BLOOD-PRESSURE REGULATION IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)

被引：4
|
作者：
GLAZEWSKI, S
REMISZEWSKA, M
WUTKIEWICZ, M
JASTRZEBSKI, Z
DANYSZ, W
机构：
[1] M NENCKI INST EXPTL BIOL, DEPT NEUROPHYSIOL, PL-02093 WARSAW, POLAND
[2] INST DRUG RES & CONTROL, DEPT PHARMACOL, WARSAW, POLAND
来源：
AMINO ACIDS | 1995年 / 8卷 / 04期
关键词：
AMINO ACIDS; AUTORADIOGRAPHY; H-3] MK-801; SHR; WKY RATS; BLOOD PRESSURE; HYPERTENSION;
D O I：
10.1007/BF00806555
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study the binding of [H-3]MK-801 to glutamatergic receptors of the NMDA type was compared in spontaneously hypertensive (SHR) and normotensive (WKY) rats in various brain structures (including nucleus tractus solitarii) by quantitative receptor autoradiography. Additionally, blood pressure changes after treatment with the NMDA antagonist MK-801 were studied in both strains. There were no differences between SHR and WKY rats either in the level of [H-3]MK-801 binding or in the hypertensive reaction to MK-801.
引用
收藏
页码：379 / 383
页数：5
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