KERAMAPHIDIN-B, A NOVEL PENTACYCLIC ALKALOID FROM A MARINE SPONGE AMPHIMEDON SP - A PLAUSIBLE BIOGENETIC PRECURSOR OF MANZAMINE ALKALOIDS

被引：69

作者：

KOBAYASHI, J ^{[1
]}

TSUDA, M ^{[1
]}

KAWASAKI, N ^{[1
]}

MATSUMOTO, K ^{[1
]}

ADACHI, T ^{[1
]}

机构：

[1] TAISHO PHARMACEUT CO LTD, RES CTR, OMIYA, SAITAMA 330, JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(00)73362-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Keramaphidin B (1), a novel cytotoxic alkaloid possessing a 1,4-etheno-2,7-decahydronaphthylidine core with two macrocyclic rings has been isolated from an Okinawan marine sponge Amphimedon sp., and the structure was elucidated by extensive 2D NMR investigation as well as a single crystal X-ray analysis. Keramaphidin B (1) might he a plausible biogenetic precursor of manzamine alkaloids and a very important key compound to clarify the biogenetic path.

引用

页码：4383 / 4386

页数：4

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