SYNERGISTIC INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION BY 5-ETHYL-1-ETHOXYMETHYL-6-(PHENYLTHIO)URACIL (E-EPU) AND AZIDOTHYMIDINE INVITRO

被引：21
作者：
BABA, M
ITO, M
SHIGETA, S
TANAKA, H
MIYASAKA, T
UBASAWA, M
UMEZU, K
WALKER, RT
DECLERCQ, E
机构：
[1] SHOWA UNIV,DEPT SYNTHET CHEM,TOKYO 142,JAPAN
[2] MITSUBISHI KASEI CORP,RES CTR,YOKOHAMA 227,JAPAN
[3] UNIV BIRMINGHAM,DEPT CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[4] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 07期
关键词：
D O I：
10.1128/AAC.35.7.1430
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A novel 6-substituted acyclouridine derivative, 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU), has recently proved to be a highly potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. Combinations of 3'-azido-2',3'-dideoxythymidine (AZT) and E-EPU synergistically inhibit the replication of HIV-1 in MT-4 cells, whereas the cytotoxic effects of AZT and E-EPU on mock-infected MT-4 cells are not enhanced by the drug combination. Synergistic inhibition of HIV-1 replication has also been observed in peripheral blood lymphocytes. These results indicate that the combination of AZT and E-EPU should be further pursued in the treatment of AIDS.
引用
收藏
页码：1430 / 1433
页数：4
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