CALCIUM-CHANNEL BLOCKADE (ISRADIPINE) IN TREATMENT OF HYPERTENSION IN PREGNANCY - A RANDOMIZED PLACEBO-CONTROLLED STUDY

被引：46

作者：

WIDESWENSSON, DH

INGEMARSSON, I

LUNELL, NO

FORMAN, A

SKAJAA, K

LINDBERG, B

LINDEBERG, S

MARSAL, K

ANDERSSON, KE

机构：

[1] HOSP OREBRO, DEPT OBSTET & GYNECOL, MALMO, SWEDEN

[2] KAROLINSKA INST, HUDDINGE UNIV HOSP, DEPT OBSTET & GYNECOL, LUND, SWEDEN

[3] AARHUS UNIV HOSP, DEPT OBSTET & GYNECOL, DK-8000 AARHUS, DENMARK

[4] UNIV UPPSALA HOSP, DEPT OBSTET & GYNECOL, UPPSALA, SWEDEN

[5] LUND UNIV, MALMO HOSP, DEPT OBSTET & GYNECOL, S-22100 LUND, SWEDEN

[6] LUND UNIV, DEPT CLIN PHARMACOL, S-22100 LUND, SWEDEN

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1995年 / 173卷 / 03期

关键词：

ISRADIPINE; PREGNANCY; HYPERTENSION; PREECLAMPSIA; DRUGS; TREATMENT;

D O I：

10.1016/0002-9378(95)90357-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy. STUDY DESIGN: The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine versus placebo. Fifty-four women were randomized to treatment with isradipine slow-release capsules given orally 5 mg twice a day and 57 to a placebo group. RESULTS: Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment. Blood flow in the umbilical artery and maternal renal and liver function were not influenced by treatment. Isradipine had few side effects and was well tolerated. CONCLUSION: Calcium channel blockade with isradipine is effective for treatment of nonproteinuric hypertension but not in preeclampsia.

引用

页码：872 / 878

页数：7

共 50 条

[31] Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial [J].

Luyun Fan ;

Junru Chen ;

Qi Zhang ;

Jie Ren ;

Youren Chen ;

Jinfeng Yang ;

Lu Wang ;

Zihong Guo ;

Peili Bu ;

Bingpo Zhu ;

Yanyan Zhao ;

Yang Wang ;

Xiaoyan Liu ;

Wenjie Wang ;

Zhenzhen Chen ;

Qiannan Gao ;

Lemin Zheng ;

Jun Cai .

Microbiome, 13 (1)

[32] Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial [J].

Verhaar, Barbara J. H. ;

Wijdeveld, Madelief ;

Wortelboer, Koen ;

Rampanelli, Elena ;

Levels, Johannes H. M. ;

Collard, Didier ;

Cammenga, Marianne ;

Nageswaran, Vanasa ;

Haghikia, Arash ;

Landmesser, Ulf ;

Li, Xinmin S. ;

Didonato, Joseph A. ;

Hazen, Stanley L. ;

Garrelds, Ingrid M. ;

Danser, A. H. Jan ;

van den Born, Bert-Jan H. ;

Nieuwdorp, Max ;

Muller, Majon .

HYPERTENSION, 2024, 81 (10) :2124-2136

[33] The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial [J].

Ali Movahed ;

Afshin Ostovar ;

Daryoush Iranpour ;

Sijo Joseph Thandapilly ;

Pema Raj ;

Xavier Lieben Louis ;

James Michael Smoliga ;

Thomas Netticadan .

Trials, 17

[34] The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial [J].

Movahed, Ali ;

Ostovar, Afshin ;

Iranpour, Daryoush ;

Thandapilly, Sijo Joseph ;

Raj, Pema ;

Louis, Xavier Lieben ;

Smoliga, James Michael ;

Netticadan, Thomas .

TRIALS, 2016, 17

[35] Randomized, double-blind, placebo-controlled trial of nicotine replacement therapy in pregnancy [J].

Kapur, B ;

Hackman, R ;

Selby, P ;

Klein, J ;

Koren, G .

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2001, 62 (04) :274-278

[36] Cervical Ripening in the Third Trimester of Pregnancy with Intravaginal Misoprostol: A Double-blind, Randomized,Placebo-controlled Study [J].

王泽华 ;

李慰玑 ;

欧阳为相 ;

丁玉莲 ;

王峰 ;

徐柳青 ;

苏晓文 .

JournalofTongjiMedicalUniversity, 1998, (03) :183-186

[37] Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study [J].

Gunawardhana, Lhanoo ;

McLean, Lachy ;

Punzi, Henry A. ;

Hunt, Barbara ;

Palmer, Robert N. ;

Whelton, Andrew ;

Feig, Daniel I. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (11)

[38] TREATMENT OF HYPERTENSION WITH ISRADIPINE, A NEW CALCIUM BLOCKING-AGENT - A STUDY CONTROLLED BY 24 HR BLOOD-PRESSURE MONITORING [J].

FASCE, E ;

LECANNELIER, E .

REVISTA MEDICA DE CHILE, 1992, 120 (06) :657-660

[39] Cervical ripening in the third trimester of pregnancy with intravaginal misoprostol: A double-blind, randomized, placebo-controlled study [J].

Wang Zehua ;

Li Weiji ;

Ouyang Weixiang ;

Ding Yulian ;

Wang Feng ;

Xu Liuqing ;

Su Xiaowen .

Current Medical Science, 1998, 18 (3) :183-186

[40] The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: A randomized placebo-controlled study [J].

Hofmeyr, G. Justus ;

Seuc, Armando ;

Betran, Ana Pilar ;

Cormick, Gabriela ;

Singata, Mandisa ;

Fawcus, Sue ;

Mose, Simpiwe ;

Frank, Karlyn ;

Hall, David ;

Belizan, Jose ;

Roberts, James M. ;

Magee, Laura A. ;

von Dadelszen, Peter .

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 2021, 23 :91-96

← 1 2 3 4 5 →