SUPPRESSION OF SACCHARIN-INDUCED MUTAGENICITY BY INTERFERON-ALPHA IN HUMAN RSA CELLS

被引：0

作者：

SUZUKI, N ^{[1
]}

SUZUKI, H ^{[1
]}

机构：

[1] TOKYO METROPOLITAN RES LAB PUBL HLTH,SHINJUKU KU,TOKYO 169,JAPAN

来源：

CANCER RESEARCH | 1995年 / 55卷 / 19期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Saccharin is an artificial sweetener commonly used in the formulation of foods and beverages. Sodium saccharin-induced mutagenicity is detectable in human RSa cells by estimation of cloning efficiency of ouabain-resistant mutant cells and determination of K-ras codon 12 mutation in genomic DNA, analyzed by PCR and differential dot-blot hybridization. However, in this study no phenotypic or genetic mutations were detected in RSa cells cultured with human IFN (HuIFN)-alpha before sodium saccharin treatment. The suppressive effect was lessened by transient treatment with antipain immediately after sodium saccharin treatment. Elevation of antipain-sensitive protease activity was found, furthermore, in RSa cells cultured with HuIFN-alpha and subsequently treated with sodium saccharin. Thus, antipain-sensitive protease induction in cells tested here may be involved in suppression of the mutagenicity of saccharin by HuIFN-alpha.

引用

页码：4253 / 4256

页数：4

共 20 条

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