DIFFERENCE IN PRESSOR-RESPONSES TO NG-MONOMETHYL-L-ARGININE BETWEEN CONSCIOUS AND ANESTHETIZED RATS

被引：24

作者：

AISAKA, K ^{[1
]}

MITANI, A ^{[1
]}

KITAJIMA, Y ^{[1
]}

OHNO, T ^{[1
]}

ISHIHARA, T ^{[1
]}

机构：

[1] SUNTORY INST BIOMED RES,GENE TECHNOL LAB,OSAKA 618,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 56卷 / 02期

关键词：

D O I：

10.1254/jjp.56.245

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

N(G)-Monomethyl-L-arginine (L-NMMA; 0.1 - 10 mg/kg, i.v.), a selective inhibitor of nitric oxide (NO) synthesis derived from L-arginine, elicited a greater increase in blood pressure in urethane/alpha-chloralose- and pentobarbital-anesthetized rats than in conscious Wistar rats. The pressor response to phenylephrine was almost equivalent in both conscious and anesthetized rats. These findings suggest that the experimental conditions (anesthetized or conscious) modify the spontaneously released NO's contribution to blood pressure regulation in vivo.

引用

页码：245 / 248

页数：4

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