BUFFERED VERSUS PLAIN LIDOCAINE AS A LOCAL-ANESTHETIC FOR SIMPLE LACERATION REPAIR

被引：70

作者：

BARTFIELD, JM ^{[1
]}

GENNIS, P ^{[1
]}

BARBERA, J ^{[1
]}

BREUER, B ^{[1
]}

GALLAGHER, EJ ^{[1
]}

机构：

[1] BRONX MUNICIPAL HOSP CTR,DEPT AMBULATORY CARE,DIV EMERGENCY MED,BRONX,NY 10461

来源：

ANNALS OF EMERGENCY MEDICINE | 1990年 / 19卷 / 12期

关键词：

lidocaine;

D O I：

10.1016/S0196-0644(05)82603-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: Buffered lidocaine was compared with plain lidocaine as a local anesthetic for simple lacerations. Design: Randomized, double-blind, prospective clinical trial. Setting: Urban emergency department. Type of participants: Ninety-one adult patients with simple linear lacerations were enrolled. Patients with allergy to lidocaine and patients with an abnormal mental status were excluded. Interventions: Each wound edge was anesthetized with either plain or buffered lidocaine using a randomized, double-blind protocol. The pain of infiltration was measured with a previously validated visual analog pain scale. Measurements and main results: Analysis of pooled data and paired data (using patients as their own controls) revealed that infiltrating buffered lidocaine was significantly less painful than plain lidocaine (P = .03 and P = .02, respectively). There was no significant difference in the anesthetic effectiveness of the two agents during suturing. Conclusion: Buffered lidocaine is preferable to plain lidocaine as a local anesthetic agent for the repair of simple lacerations. © 1990 American College of Emergency Physicians.

引用

页码：1387 / 1389

页数：3

共 14 条

[1]

Wightman, Vaughan, Comparison of compounds used for intradermal anesthesia, Anesthesiology, 45, pp. 687-689, (1976)

[2]

Christoph, Buchanan, Begalla, Et al., Pain reduction in local anesthetic administration through pH buffering, Ann Emerg Med, 17, pp. 117-120, (1988)

[3]

McKay, Morris, Mushlin, Sodium bicarbonate attenuates pain on infiltration with lidocaine with or without epinephrine, Anesthesiology, 66, pp. 572-574, (1987)

[4]

Scott, Huskisson, Graphic representation of pain, Pain, 2, pp. 175-184, (1976)

[5]

DeJung, Local Anesthetics, pp. 42-50, (1977)

[6]

Moore, The pH of local anesthetic solutions, Anesth Analg, 60, pp. 833-834, (1981)

[7]

Ritchie, Greene, Local anesthetics, The Pharmacologic Basis of Therapeutics, pp. 302-321, (1985)

[8]

Ritchie, Ritchie, Greengard, The active structure of local anesthetics, J Pharmacol Exp Ther, 150, pp. 152-159, (1965)

[9]

Cheney, Molzen, Tandberg, The effect of pH buffering on reducing the pain associated with subcutaneous injection of bupivicaine, Ann Emerg Med, 19, (1990)

[10]

DiFazio, Carron, Grosslight, Et al., Comparison of pH-adjusted lidocaine solutions for epidural anesthesia, Anesth Analg, 65, pp. 760-764, (1986)

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