AN IMPROVED SYNTHESIS OF PYRROLES FROM N-PARA-TOLUENESULFONYLGLYCINE ESTERS AND ALPHA,BETA-UNSATURATED ALDEHYDES AND KETONES

被引：31
作者：
LASH, TD
HOEHNER, MC
机构：
[1] Department of Chemistry, Illinois State University, Normal, Illinois
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 07期
关键词：
D O I：
10.1002/jhet.5570280705
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-p-Toluenesulfonylglycine esters 2 condensed with alpha,beta-unsaturated carbonyl compounds 1 in the presence of the non-nucleophilic base DBU to give hydroxypyrrolidines 3. Dehydration with phosphorus oxychloride-pyridine, followed by DBU mediated elimination of p-toluenesulfinic acid, gave a series of synthetically useful pyrrole-2-carboxylates 5.
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页码：1671 / 1676
页数：6
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