X-RAY CONFORMATIONAL STUDY OF HYDRAZINO PEPTIDE ANALOGS

被引：42

作者：

AUBRY, A

BAYEUL, D

MANGEOT, JP

VIDAL, J

STERIN, S

COLLET, A

LECOQ, A

MARRAUD, M

机构：

[1] ECOLE NORMALE SUPER LYON,CNRS,UM 117,F-69364 LYONS 07,FRANCE

[2] INST NATL POLYTECH LORRAINE,ECOLE NATL SUPER IND CHIM,CNRS,URA 494,F-54001 NANCY,FRANCE

来源：

BIOPOLYMERS | 1991年 / 31卷 / 06期

关键词：

D O I：

10.1002/bip.360310625

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have solved the crystal structures of nine pseudo-peptide analogues deriving from the hydrazino analogue of glycine or valine (N-beta-H-2-N-alpha-H-C-alpha-HR-CO2H, R = H or iPr) or proline (N-beta-H-2-N-alpha-C-alpha-H-CO2H) and containing the hydrazide (CO-N-beta-H-N-alpha <) or N-beta-Z-aminoamide [GRAPHICS] [CO-N-alpha(N-beta-HZ)] peptidomimetic link. This study gives access to the average geometry of these two links, to their inter- and intramolecular interaction modes, and to their influence on the conformational properties of the molecules.

引用

页码：793 / 801

页数：9

共 20 条

[1] PIVALOYL-L-PROLYL-N'-ISOPROPYLGLYCINAMIDE [J].