THE DIVERGENCE BETWEEN 2 ONCOGENIC HERPESVIRUS-SAIMIRI STRAINS IN A GENOMIC REGION RELATED TO THE TRANSFORMING PHENOTYPE

被引:113
作者
BIESINGER, B [1 ]
TRIMBLE, JJ [1 ]
DESROSIERS, RC [1 ]
FLECKENSTEIN, B [1 ]
机构
[1] HARVARD UNIV,SCH MED,NEW ENGLAND REG PRIMATE RES CTR,SOUTHBOROUGH,MA 01772
关键词
D O I
10.1016/0042-6822(90)90020-R
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Herpesvirus saimiri strains can be divided into at least three subgroups (A, B, C) based on sequence divergence at the left end of viral unique sequence DNA. Strains of subgroups A and C are highly oncogenic and readily transform simian T-lymphocytes in vitro to interleukin-2 independent growth, while subgroup B strains do not. A left terminal reading frame of a H. saimiri subgroup A strain was shown previously to correlate with the oncogenic phenotype and in vitro transforming potential; the deduced polypeptide was termed STP-A. Furthermore, this same region contains an open reading frame (ORF) for dihydrofolate reductase (DHFR) and genes for five virus-specific U RNAs (HSURs). We now show by sequence analysis of the corresponding region in a subgroup C strain that DHFR and HSUR genes are present in both virus subgroups; however, no sequence homologous to the STP-A reading frame was found in this subgroup C virus. At a position and orientation similar to STP-A, two ORFs were found for peptides sharing a putative transmembrane domain. One of them encodes a peptide with collagen-like repetitions. In addition to the lack of similarity to STP-A, these two reading frames also did not show any similarity to known oncogenes. The organization of sequences at the left junction of unique L- and repetitive H-DNA of H. saimiri suggests frequent recombinational events, possibly accelerating the uptake of foreign genes by the virus. © 1990.
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页码:505 / 514
页数:10
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