MR-IMAGING WITH HYPERPOLARIZED HE-3 GAS

被引：319

作者：

MIDDLETON, H

BLACK, RD

SAAM, B

CATES, GD

COFER, GP

GUENTHER, R

HAPPER, W

HEDLUND, LW

JOHNSON, GA

JUVAN, K

SWARTZ, J

机构：

[1] DUKE UNIV,MED CTR,CTR IN VIVO MICROSCOPY,DURHAM,NC

[2] DUKE UNIV,DEPT BIOMED ENGN,DURHAM,NC 27706

[3] DUKE UNIV,DEPT PHYS,DURHAM,NC 27706

来源：

MAGNETIC RESONANCE IN MEDICINE | 1995年 / 33卷 / 02期

关键词：

MRI; GAS; HELIUM; HYPERPOLARIZED;

D O I：

10.1002/mrm.1910330219

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Magnetic resonance images of the lungs of a guinea pig have been produced using hyperpolarized helium as the source of the MR signal. The resulting images are not yet sufficiently optimized to reveal fine structural detail within the lung, but the spectacular signal from this normally signal-deficient organ system offers great promise for eventual in vivo imaging experiments. Fast 2D and 3D GRASS sequences with very small flip angles were employed to conserve the nonrenewable longitudinal magnetization. We discuss various unique features associated with performing MRI with hyperpolarized gases, such as the selection of the noble gas species, polarization technique, and constraints on the MR pulse sequence.

引用

页码：271 / 275

页数：5

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