BLOCKADE OF NEUROTRANSMITTER-ACTIVATED K+ CONDUCTANCE BY QX-314 IN THE RAT HIPPOCAMPUS

被引：86
作者：
ANDRADE, R
机构：
[1] Department of Pharmacological and Physiological Sciences, St. Louis University School of Medicine, St. Louis, MO 63104
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 02期
关键词：
QX-314; K+ CHANNELS; 5-HT1A RECEPTORS; GABA-B RECEPTORS;
D O I：
10.1016/0014-2999(91)90467-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Intracellular injection of QX-314 blocked the ability of baclofen and 5-carboxyamidotryptamine to hyperpolarize cells in the rat hippocampus. This effect was not associated with a reduction in the effects of norepinephrine on these cells nor a blockade of the potassium channels underlying the calcium-dependent afterhyperpolarization responsible or significant changes in membrane potential. These results suggest that QX-314 is an effective blocker of G-protein-gated potassium channels in this region.
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页码：259 / 262
页数：4
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