BLOCKADE OF NEUROTRANSMITTER-ACTIVATED K+ CONDUCTANCE BY QX-314 IN THE RAT HIPPOCAMPUS

被引：86

作者：

ANDRADE, R

机构：

[1] Department of Pharmacological and Physiological Sciences, St. Louis University School of Medicine, St. Louis, MO 63104

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 02期

关键词：

QX-314; K+ CHANNELS; 5-HT1A RECEPTORS; GABA-B RECEPTORS;

D O I：

10.1016/0014-2999(91)90467-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intracellular injection of QX-314 blocked the ability of baclofen and 5-carboxyamidotryptamine to hyperpolarize cells in the rat hippocampus. This effect was not associated with a reduction in the effects of norepinephrine on these cells nor a blockade of the potassium channels underlying the calcium-dependent afterhyperpolarization responsible or significant changes in membrane potential. These results suggest that QX-314 is an effective blocker of G-protein-gated potassium channels in this region.

引用

页码：259 / 262

页数：4

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