EFFECT OF SIZE, SHAPE AND HARDNESS OF PARTICLES IN SUSPENSION ON ORAL PALATABILITY

被引：6

作者：

TYLE, P

KUENN, C

GEIER, L

JAROSZ, P

机构：

[1] Sandoz Research Institute, Sandoz Pharmaceuticals Corporation, Pharmaceutical Research and Development, Lincoln, NB, 68501

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 08期

关键词：

D O I：

10.3109/03639049009115965

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The size, shape. and hardness of particles in suspension can influence the oral sensory perception and palatability. This information can be used in the design of a suspension dosage form or to define optimal parameters for a reconstitutible oral delivery system. The report summarizes the effect of garnet, polyethylene and mica suspension on texture, taste and consistency. Significant differences in sensory perception exist between different samples based on the size, shape or hardness of the particles. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1339 / 1364

页数：26

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