REPRESSION VERSUS ACTIVATION IN THE CONTROL OF GENE-TRANSCRIPTION

被引：175

作者：

COWELL, IG

机构：

[1] I. G. Cowell is at the Department of Biochemistry and Genetics, The Medical School, University of Newcastle Upon Tyne, Newcastle Upon Tyne

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 01期

关键词：

D O I：

10.1016/0968-0004(94)90172-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies on the regulation of transcription often focus on mechanisms of transcriptional activation. However, transcriptional repression is also an important factor in the regulation of many genes. Transcription of specific genes can be downregulated in various ways, and examination of a number of different systems has revealed that most or all steps required for transcriptional activation can be interfered with by transcriptional repressors.

引用

页码：38 / 42

页数：5

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