SYNTHESIS AND ANTITUMOR-ACTIVITY OF FUSED QUINOLINE DERIVATIVES .3. NOVEL N-GLYCOSYLAMINOINDOLO[3,2-B]QUINOLINES

被引：0
|
作者：
TAKEUCHI, Y
CHANG, MR
HASHIGAKI, K
TASHIRO, T
TSURUO, T
TSUKAGOSHI, S
YAMATO, M
机构：
[1] OKAYAMA UNIV, FAC PHARMACEUT SCI, TSUSHIMANAKA 1-1-1, OKAYAMA 700, JAPAN
[2] CANC CHEMOTHERAPY CTR, TOSHIMA KU, TOKYO 170, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 06期
关键词：
INDOLO[3,2-B]QUINOLINE; GLYCOSYLATION; ANTITUMOR ACTIVITY; P388; LEUKEMIA;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel indolo[3,2-b]quinolines (1b-k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (1g) showed the most potent activity (optimal dose = 25 mg/kg, T/C > 333%, cure rate 5/6).
引用
收藏
页码：1481 / 1485
页数：5
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