CORRELATIONS BETWEEN THE SERUM APOLIPOPROTEIN A-I, A-II, B, C-II, C-III, AND E-LEVELS AND CHOLINESTERASE IN VARIOUS HYPERLIPIDEMIAS

We measured the serum apolipoprotein (Apo) levels in various hyperlipidemias and determined their correlations with the serum cholinesterase and albumin levels. The objective was to elucidate which apolipoprotein(s) commonly reflects the liver function, as shown by the albumin and cholinesterase levels, in various hyperlipidemias. The subjects consisted of 53 normal controls and 86 type IIa, 38 type IIb, 28 type IV, and 9 type V hyperlipidemias. Each apolipoprotein level generally reflected the characteristic changes of lipoproteins for each hyperlipidemia. As for the correlation of apolipoproteins with cholinesterase and albumin, Apo A-II showed a positive correlation with cholinesterase in the normal controls and in all types of hyperlipidemia, though it was not significant in types IIb and V. And Apo A-II also showed a significantly positive correlation with albumin in all types of hyperlipidemia except type V. Considering that cholinesterase and albumin are known to reflect the liver function, these results are consistent with the idea that among the various apolipoproteins, Apo A-II may best reflect the liver function in all types of hyperlipidemia.