DNA ANALYSIS BY FLOW-CYTOMETRY IN NONSMALL CELL LUNG-CANCER - RELATIONSHIP TO EPIDERMAL GROWTH-FACTOR RECEPTOR, HISTOLOGY, TUMOR STAGE AND SURVIVAL

被引：35

作者：

DAZZI, H

THATCHER, N

HASLETON, PS

SWINDELL, R

机构：

[1] CHRISTIE HOSP & HOLT RADIUM INST,CANC RES CAMPAIGN,DEPT MED ONCOL,MANCHESTER M20 9BX,LANCS,ENGLAND

[2] CHRISTIE HOSP & HOLT RADIUM INST,DEPT MED STAT,MANCHESTER M20 9BX,LANCS,ENGLAND

[3] WYTHENSHAWE HOSP,DEPT HISTOPATHOL,MANCHESTER M23 9LT,LANCS,ENGLAND

来源：

RESPIRATORY MEDICINE | 1990年 / 84卷 / 03期

关键词：

D O I：

10.1016/S0954-6111(08)80038-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P<0·02). A high proliferation index (>7·5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor. © 1990, Baillière Tindall. All rights reserved.

引用

页码：217 / 223

页数：7

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