DEPOLARIZATION-INDUCED RELEASE OF GLYCINE AND BETA-ALANINE FROM PLASMA-MEMBRANE VESICLES DERIVED FROM RAT-BRAIN SYNAPTOSOMES

被引：0

作者：

ARAGON, MC ^{[1
]}

AGULLO, L ^{[1
]}

GIMENEZ, C ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, FAC CIENCIAS, CTR BIOL MOLEC, E-28049 MADRID, SPAIN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1988年 / 941卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycine and .beta.-alanine actively loaded into brain synaptic plasma membrane vesicles were released into the external medium by using the classical depolarization agents high K+ and veratridine. This release occurs via a Ca2+-independent process. Measurements of membrane depolarization using tetraphenylphosphonium uptake show a close correlation between changes in the membrane potential and stimulation of the efflux process. Results shown herein and previously reported by our group (Aragon, M.C. and Gimenez, C. (1986) Biochim. Biophys. Acta 855, 257-264; Agullo, L., Jimenez, B. Aragon, M.C. and Gimenez, C. (1986) Eur. J. Biochem. 159, 611-617), suggest that the glycine and .beta.-alanine transport systems in synaptic plasma membranes are susceptible of modulation by changes in ionic fluxes and hence in the membrane potential, similar to those occurring during depolarization and repolarization.

引用

页码：209 / 216

页数：8

共 56 条

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