SUCCESSFUL ALLOTRANSPLANTATION OF MICROENCAPSULATED PARATHYROIDS IN RATS

被引：28
作者：
HASSE, C
SCHREZENMEIR, J
STINNER, B
SCHARK, C
WAGNER, PK
NEUMANN, K
ROTHMUND, M
机构：
[1] UNIV MAINZ,DEPT ENDOCRINOL,MED CLIN 3,D-55131 MAINZ,GERMANY
[2] UNIV MARBURG,DEPT PATHOL,D-35033 MARBURG,GERMANY
来源：
WORLD JOURNAL OF SURGERY | 1994年 / 18卷 / 04期
关键词：
D O I：
10.1007/BF00353783
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Allotransplantation of parathyroid tissue in humans is desirable for treating long-term hypoparathyroidism (e;g., after inadvertent removal of parathyroid glands during thyroid surgery). Until now, parathyroid allotransplantation was not used clinically because its advantages were outweighted by the need of immunosuppression. To overcome the immunogenicity of the tissue to be transplanted, we employed the method of microencapsulation; first tried in islet cell transplantation for experimental allotransplantation of parathyroid tissue. We have been able to achieve long-term success in a rat model. After isolation and tissue culture, tissue pieces from parathyroid glands of 280 Lewis rats were encapsulated in barium alginate and grafted into hypocalcemic DA rats. From the 7th to the 90th day after transplantation the recipient rats (DA rats) showed a normal serum calcium concentration. This is the first report of successful long-term survival and function of microencapsulated allotransplanted parathyroid tissue.
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页码：630 / 634
页数：5
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