Mesenchymal stromal cells and immune tolerance: towards clinical applications?

被引:0
作者
Noel, DaniSle [1 ,2 ,3 ]
Djouad, Farida [2 ,3 ,4 ]
Mrugala, Dominique [2 ,3 ]
Bouffi, Carine [2 ,3 ]
Jorgensen, Christian [2 ,3 ,5 ]
机构
[1] INSERM, U844, F-34091 Montpellier, France
[2] Univ Montpellier I, UFR Med, F-34000 Montpellier, France
[3] Hop St Eloi, Unite Thrapie Cellulaire & Gene, F-34295 Montpellier, France
[4] NIH, Cartilage Biol & Orthopaed Branch, Bethesda, MD 20892 USA
[5] Hop Lapeyronie, Serv Immuno Rhumatol, F-34295 Montpellier, France
来源
HEMATOLOGIE | 2007年 / 13卷 / 04期
关键词
mesenchymal stem cell; immunosuppression; characterization;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Multipotent mesenchymal stromal cells, or mesenchymal stem cells (MSC), are isolated mainly from bone marrow and adipose tissue but are identified in other tissues such as synovium, periosteum or placenta. They are characterized by their property to adhere to plastic, their phenotype and their ability to differentiate into three lineages (chondrocytes, osteoblasts and adipocytes). More recently, these cells were shown to escape immune recognition and inhibit immune responses. MSC may modulate the function of the major immune cell populations, including antigen-presenting cells, T cells, B cells and natural killer cells. The aim of this review is to focus on the molecular mechanisms, still poorly understood, which are responsible of the immunosuppressive effects mediated by the MSC. Finally, the data obtained from in vivo experimentation in various animal models as well as potential therapeutic applications will be presented.
引用
收藏
页码:235 / 242
页数:8
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