SPIROKETAL GLYCOMIMETICS - THE SYNTHESIS OF A CONFORMATIONALLY RESTRAINED SIALYL-LEWIS-X MIMIC

被引：22

作者：

BIRKBECK, AA

LEY, SV

PRODGER, JC

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND

[2] GLAXO RES & DEV LTD,MED RES CTR,DEPT BIOMOLEC STRUCT,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 22期

关键词：

D O I：

10.1016/0960-894X(95)00469-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a spiroketal scaffold and its specific elaboration with N-acetyl neuraminic acid and fucose monosaccharides to yield the conformationally restrained Sialyl Lewis X mimic 2 is described.

引用

页码：2637 / 2642

页数：6

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