SPECTROPHOTOMETRIC DETERMINATION OF FLUVOXAMINE IN TABLETS BASED ON CHARGE-TRANSFER COMPLEX WITH CHLORANIL

Fluvoxamine was reacted with chloranil in aqueous ethanolic medium buffered at pH 9 to yield a complex with maximum absorption at 347 nm. The estimated molar absorptivity and stability constant of the complex were (1.30 +/- 0.03) x 10(4) L mol-1 cm-1 and (1.7 +/- 0.5) x 10(4) L mol-1 respectively. Absorbance at (lambda(max)) was linearly related to concentration of fluvoaxamine over the range 2 to 25 mug ml-1 with a detection limit of 0.4 mug ml-1. The slopes of log-log plots of initial concentrations of fluvoxamine or chloranil vs. initial rate of color development were both unity. When the reaction was applied to commercial tablets (Faverin(R)-50) labeled to contain 50 mg of fluvoxamine maleate per tablet, the mean percentage found was 100.4 +/- 1.0. Recovery experiments after standard additions and analysis of variance (ANOVA) were carried out to [GRAPHICS] investigate the accuracy and precision of the proposed method. Reversed-phase high-performance liquid chromatography, (RP-HPLC), using mu-Bondapak C18 (30 cm X 3.9 mm, i.d.) column, mobile phase consisting of 80% V/V-CH3CN + 20% v/v CH3COONa (0.01 M) buffer (adjusted to pH 3.5 with CH3COOH) and ultraviolet light detection was adopted for the quantitation of the commercial tablets. The results obtained by the RP-HPLC method were compared with those obtained by the proposed one.