CHANGES IN THE STRENGTH OF RECURRENT INHIBITION IN COBALT-INDUCED EPILEPSY

被引：3

作者：

KAWAKAMI, Y

KOYAMA, I

机构：

[1] Department of Physiology, Tokyo Women's Medical College, Tokyo

来源：

EPILEPSIA | 1992年 / 33卷 / 03期

关键词：

CONVULSIONS; NEUROLOGIC MODELS; COBALT; AFTERDISCHARGES; RECURRENT INHIBITION; THALAMUS;

D O I：

10.1111/j.1528-1157.1992.tb01686.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Changes in the strength of recurrent inhibition in the feline cortex in cobalt (CoCl2)-induced epilepsy were observed. The strength of inhibition was analyzed in terms of paired-pulse depression of the amplitude of somatosensory evoked potentials (SEPs) elicited by stimulation of the ventral posterolateral (VPL) thalamic nucleus. An enhancement in recurrent inhibition was observed shortly after CoCl2 application. The size of the amplitude of cortical evoked potentials (EPs) elicited by VPL stimulation increased simultaneously. The reduction of inhibition that appeared later was associated with afterdischarges (ADs) evoked by VPL stimulation. These ADs frequently extended to epileptic discharges. These results suggest that the reduction in recurrent inhibition induced by CoCl2 application plays an important role in the spread of seizure activity.

引用

页码：428 / 434

页数：7

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