GENOTOXIC ACTIVITY OF BENOMYL IN DIFFERENT TEST SYSTEMS

被引：45
作者：
GEORGIEVA, V
VACHKOVA, R
TZONEVA, M
KAPPAS, A
机构：
[1] AGHIA PARASKEVI ATTIKIS, NATL RES CTR DEMOCRITUS, INST BIOL, POB 60228, GR-15310 ATHENS, GREECE
[2] ACAD MED SOFIA, INST GASTROENTEROL & NUTR, SOFIA, BULGARIA
来源：
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1990年 / 16卷 / 01期
关键词：
Ames test; bone marrow cells; dominant lethals; human lymphocytes;
D O I：
10.1002/em.2850160106
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Benomyl (methyl‐1‐[butylcarbamoyl]‐2‐benzimidozole carbamate), a benzimidazole derivative fungicide, was tested in the Ames test for point mutations; in human lymphocyte cultures for cell division disturbances, chromosomal aberrations, and SCE; in rat bone marrow cells in vivo for micronuclei; and in rats in vivo for dominant lethals. Benomyl was negative in the Ames test. In human lymphocytes, benomyl at concentrations of 0.5, 1.0, and 2.0 μg/ml decreased the number of cells undergoing third division whereas at the concentrations of 0.25 to 4.0 μg/ml it strongly increased the number of aneuploid cells. Benomyl was also shown to induce sister chromatid exchanges and micronuclei but not chromosome aberrations. Benomyl decreased the number of female rats with implants but did not cause any dominant lethals. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：32 / 36
页数：5
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