METABOLISM OF TYRAMINE-3H AND OCTOPAMINE-3H BY RAT BRAIN

被引：46

作者：

BREESE, GR

CHASE, TN

KOPIN, IJ

机构：

[1] Laboratory of Clinical Science, National Institute of Mental Health, Bethesda

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 04期

关键词：

D O I：

10.1016/0006-2952(69)90057-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Octopamine-3H or tyramine-3H injected into the cisterna magna of rats is rapidly metabolized and quickly disappears from brain. The disappearance of tyramine-3H is more rapid than octopamine-3H. Monoamine oxidase inhibition diminishes the disappearance of these amines from brain, suggesting that the unaltered amines do not pass freely from brain to blood. The major metabolite formed after intracisternal injection of octopamine-3H is the neutral metabolite, 4-hydroxyphenylglycol, or its conjugate. The principle metabolite formed from tyramine-3H is 4-hydroxyphenyl-acetic acid. These findings support the contention that β-hydroxylated aldehydes formed by deamination of phenylethanolamines in cerebral tissue are reduced to glycol derivatives, while non-β-hydroxylated intermediates formed by deamination of phenyl-ethylamines are oxidized mainly to acids. © 1969.

引用

页码：863 / &

共 14 条

[1]

ANAGNOSTE BERTA, 1967, LIFE SCI, V6, P1535, DOI 10.1016/0024-3205(67)90333-5

[2]

BREESE GR, 1968, FEDN P, V27, P399

[3] IN-VIVO DECARBOXYLATION OF ALPHA-METHYL DOPA AND ALPHA-METHYL METATYROSINE [J].