Comparison of Efficacy between Intravenous Ondansetron and Intravenous Lidocaine on Propofol Induced Vascular Pain

Aim: To compare the effects of intravenous ondansetron and intravenous lidocaine on reduction of Propofol induced vascular pain. Methods: This randomized controlled trial was conducted at Department of Anaesthesia, Combined Military Hospital, Bahawalpur from November 2015 to May 2016. Total 700 patients undergoing elective surgeries, having age 18-55 years of both sexes and having ASA Grade I & II were selected for this study. Group A received Injection Lidocaine plain 2% (2ml) while group B received Ondansetron 4 mg (2 ml) at the time of induction of anesthesia. Results: Age of the patients ranged between 18-55 years. Mean age of the patients was 33.1 +/- 9.1 years and 32.6 +/- 8.9 years in group-A and group-B, respectively. In group-A, 233 (66.6%) patients and in group-B 239 (68.3%) patients were males while 117 patients (33.4%) in group-A and 111 patients (31.7%) in group-B were females. Pain reduction was observed in 224 patients (64.0%) of group-A while in group-B pain reduction was reported by 266 patients (76.0%). Conclusion: In conclusion, lidocaine pretreatment provides a simple and safe method of reducing the incidence of pain on injection of propofol and avoiding the administration of other drugs that may be undesirable in certain circumstances.