HOW ALPHA-BETA-T-CELL RECEPTORS SEE PEPTIDE MHC COMPLEXES

被引：134

作者：

CHIEN, YH ^{[1
]}

DAVIS, MM ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,HOWARD HUGHES MED INST,STANFORD,CA 94305

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期

关键词：

D O I：

10.1016/0167-5699(93)90199-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent results hate added new information to our understanding of alphabeta T-cell receptor mediated recognition. In particular, we find that the V(D)J junction or 'CDR3' portion of TCRalpha and beta seem most important in contacting peptides bound to MHC molecules, consistent with previous predictions. Surprisingly, these same CDR3-peptide contacts also appear to have a major influence on the TCR-MHC molecule interactions as well.

引用

页码：597 / 602

页数：6

共 55 条

[1] LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].

ACHAORBEA, H ;

MITCHELL, DJ ;

TIMMERMANN, L ;

WRAITH, DC ;

TAUSCH, GS ;

WALDOR, MK ;

ZAMVIL, SS ;

MCDEVITT, HO ;

STEINMAN, L .

CELL, 1988, 54 (02) :263-273

[2] EVIDENCE THAT MULTIPLE RESIDUES ON BOTH THE ALPHA-HELICES OF THE CLASS-I MHC MOLECULE ARE SIMULTANEOUSLY RECOGNIZED BY THE T-CELL RECEPTOR [J].

AJITKUMAR, P ;

GEIER, SS ;

KESARI, KV ;

BORRIELLO, F ;

NAKAGAWA, M ;

BLUESTONE, JA ;

SAPER, MA ;

WILEY, DC ;

NATHENSON, SG .

CELL, 1988, 54 (01) :47-56

[3] THE EFFECTS OF MHC GENE DOSAGE AND ALLELIC VARIATION ON T-CELL RECEPTOR SELECTION [J].

BERG, LJ ;

FRANK, GD ;

DAVIS, MM .

CELL, 1990, 60 (06) :1043-1053

[4] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[5] THE FOREIGN ANTIGEN-BINDING SITE AND T-CELL RECOGNITION REGIONS OF CLASS-I HISTOCOMPATIBILITY ANTIGENS [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :512-518

[6] 3-DIMENSIONAL STRUCTURE OF THE HUMAN CLASS-II HISTOCOMPATIBILITY ANTIGEN HLA-DR1 [J].

BROWN, JH ;

JARDETZKY, TS ;

GORGA, JC ;

STERN, LJ ;

URBAN, RG ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1993, 364 (6432) :33-39

[7] IDENTIFICATION OF A CD4 BINDING-SITE ON THE BETA-2-DOMAIN OF HLA-DR MOLECULES [J].

CAMMAROTA, G ;

SCHEIRLE, A ;

TAKACS, B ;

DORAN, DM ;

KNORR, R ;

BANNWARTH, W ;

GUARDIOLA, J ;

SINIGAGLIA, F .

NATURE, 1992, 356 (6372) :799-801

[8] ANTIGEN-SELECTED T-CELL RECEPTOR DIVERSITY AND SELF-NONSELF HOMOLOGY [J].

CASANOVA, JL ;

MARYANSKI, JL .

IMMUNOLOGY TODAY, 1993, 14 (08) :391-394

[9] THE OUTLINE STRUCTURE OF THE T-CELL ALPHA-BETA-RECEPTOR [J].

CHOTHIA, C ;

BOSWELL, DR ;

LESK, AM .

EMBO JOURNAL, 1988, 7 (12) :3745-3755

[10] IMPLICATIONS OF A FAB-LIKE STRUCTURE FOR THE T-CELL RECEPTOR [J].

CLAVERIE, JM ;

PROCHNICKACHALUFOUR, A ;

BOUGUELERET, L .

IMMUNOLOGY TODAY, 1989, 10 (01) :10-14

← 1 2 3 4 5 6 →