HOW ALPHA-BETA-T-CELL RECEPTORS SEE PEPTIDE MHC COMPLEXES

被引：134
|
作者：
CHIEN, YH [1 ]
DAVIS, MM [1 ]
机构：
[1] STANFORD UNIV,MED CTR,SCH MED,HOWARD HUGHES MED INST,STANFORD,CA 94305
来源：
IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期
关键词：
D O I：
10.1016/0167-5699(93)90199-U
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent results hate added new information to our understanding of alphabeta T-cell receptor mediated recognition. In particular, we find that the V(D)J junction or 'CDR3' portion of TCRalpha and beta seem most important in contacting peptides bound to MHC molecules, consistent with previous predictions. Surprisingly, these same CDR3-peptide contacts also appear to have a major influence on the TCR-MHC molecule interactions as well.
引用
收藏
页码：597 / 602
页数：6
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