EXPRESSION OF NEUROPEPTIDES IN THE RAT MESENCEPHALIC TRIGEMINAL NUCLEUS AFTER PERIPHERAL AXOTOMY

被引：22

作者：

ARVIDSSON, J

RAAPPANA, P

DIEZ, M

HOKFELT, T

机构：

[1] Department of Neuroscience, Karolinska Institutet, Stockholm

来源：

NEUROREPORT | 1994年 / 5卷 / 10期

关键词：

NEUROPEPTIDE Y; GALANIN; UP-REGULATION; PROPRIOCEPTIVE NEURONS; PERIPHERAL AXOTOMY;

D O I：

10.1097/00001756-199406020-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CERTAIN populations of dorsal root ganglion cells upregulate galanin (GAL) and neuropeptide Y (NPY) after peripheral axotomy. Less is known of the functional properties of the neurones reacting in this way. The primary sensory mesencephalic trigeminal (Me5) neurones are considered to have purely proprioceptive functions. In this study immunohistochemistry and in situ hybridization have been used to investigate the expression of NPY and GAL in Me5 neurones after peripheral axotomy. Both methods revealed a transient upregulation of GAL and NPY in Me5 neurones which was first observed 3 days postoperatively, peaking at 1 and 2 weeks and then being reduced. The results show that proprioceptive neurones may upregulate these peptides as a consequence of injury.

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页码：1269 / 1272

页数：4

相关论文

共 18 条

[1] AN HRP STUDY OF THE CENTRAL PROJECTIONS FROM PRIMARY SENSORY NEURONS INNERVATING THE RAT MASSETER MUSCLE [J].

ARVIDSSON, J ;

RAAPPANA, P .

BRAIN RESEARCH, 1989, 480 (1-2) :111-118

[2] SENSITIVE MESSENGER-RNA DETECTION USING UNFIXED TISSUE - COMBINED RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

DAGERLIND, A ;

FRIBERG, K ;

BEAN, AJ ;

HOKFELT, T .

HISTOCHEMISTRY, 1992, 98 (01) :39-49

[3] PRODUCTION AND CHARACTERIZATION OF 4 ANTINEUROPEPTIDE-Y MONOCLONAL-ANTIBODIES [J].

GROUZMANN, E ;

COMOY, E ;

WALKER, P ;

BURNIER, M ;

BOHUON, C ;

WAEBER, B ;

BRUNNER, H .

HYBRIDOMA, 1992, 11 (04) :409-424

[4] GALANIN MESSAGE-ASSOCIATED PEPTIDE (GMAP)-LIKE AND GALANIN-LIKE IMMUNOREACTIVITIES - OVERLAPPING AND DIFFERENTIAL DISTRIBUTIONS IN THE RAT [J].

HOKFELT, T ;

AMAN, K ;

ARVIDSSON, U ;

BEDECS, K ;

CECCATELLI, S ;

HULTING, AL ;

LANGEL, U ;

MEISTER, B ;

PIERIBONE, V ;

BARTFAI, T .

NEUROSCIENCE LETTERS, 1992, 142 (02) :139-142

[5] INCREASE OF GALANIN-LIKE IMMUNOREACTIVITY IN RAT DORSAL-ROOT GANGLION-CELLS AFTER PERIPHERAL AXOTOMY [J].

HOKFELT, T ;

WIESENFELDHALLIN, Z ;

VILLAR, M ;

MELANDER, T .

NEUROSCIENCE LETTERS, 1987, 83 (03) :217-220

[6] MESSENGER PLASTICITY IN PRIMARY SENSORY NEURONS FOLLOWING AXOTOMY AND ITS FUNCTIONAL IMPLICATIONS [J].

HOKFELT, T ;

ZHANG, X ;

WIESENFELDHALLIN, Z .

TRENDS IN NEUROSCIENCES, 1994, 17 (01) :22-30

[7] A SIMPLE METHOD OF REDUCING THE FADING OF IMMUNOFLUORESCENCE DURING MICROSCOPY [J].

JOHNSON, GD ;

ARAUJO, GMDN .

JOURNAL OF IMMUNOLOGICAL METHODS, 1981, 43 (03) :349-350

[8] STRUCTURE AND EXPRESSION OF THE RAT NEUROPEPTIDE-Y GENE [J].

LARHAMMAR, D ;

ERICSSON, A ;

PERSSON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (07) :2068-2072

[9]

LUNDBERG JM, 1984, J NEUROSCI, V4, P2376

[10] LOCATION, MORPHOLOGY, AND CENTRAL PROJECTIONS OF MESENCEPHALIC TRIGEMINAL NEURONS INNERVATING RAT MASTICATORY MUSCLES STUDIED BY AXONAL-TRANSPORT OF CHOLERAGENOID-HORSERADISH PEROXIDASE [J].

RAAPPANA, P ;

ARVIDSSON, J .

JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 328 (01) :103-114