IMMUNOPHENOTYPE OF BLAST CELLS IN ACUTE MYELOFIBROSIS

被引：4

作者：

ORTUNO, F

SOLER, J

VILELLA, R

BORDES, R

GUANYABENS, C

RUBIOL, E

PUJOLMOIX, N

机构：

[1] HOSP SANTA CRUZ & SAN PABLO, SERV HEMATOL, AVGDA SAM CLARET 167, E-08025 BARCELONA, SPAIN

[2] HOSP SANTA CRUZ & SAN PABLO, SERV ANAT PATOL, BARCELONA, SPAIN

[3] HOSP CLIN BARCELONA, SERV IMMUNOL, BARCELONA, SPAIN

来源：

LEUKEMIA RESEARCH | 1990年 / 14卷 / 10期

关键词：

ACUTE MYELOFIBROSIS; FLOW CYTOMETRY; IMMUNOPHENOTYPE; MEGAKARYOBLASTIC LEUKEMIA; MONOCLONAL ANTIBODIES; MYELOID LEUKEMIA;

D O I：

10.1016/0145-2126(90)90173-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The immunophenotype of peripheral blood blast cells from six patients with acute myelofibrosis was studied using a panel of monoclonal antibodies directed against granulocytic, erythroid, megakaryocytic and lymphoid antigenic determinants. In all patients most of the blast cells were labeled with anti-HLA-DR and with the early myelomonocytic antibodies My7 (CD13), My9 (CD33) and B1-3C5 (CD34) (3/3). In three cases, platelet antibodies Edu3 (CD41) and GPIIIa (CD61) reacted with about 30% of blast cells. TdT was positive in two out of six samples studied. Lymphoid markers T3 (CD3), Leu9 (CD7), J5 (CD10), B4 (CD19) and B1 (CD20) were negative in all cases. These results suggest that blast cells are mainly of immature myelocytic origin. However, the coexistence of megakaryoblasts cannot be ruled out in the cases with a proportion of cells that are positive with Edu 3 and GPIIIa antibodies.

引用

页码：849 / 856

页数：8

共 37 条

[1]

AMJAD H, 1980, CANCER, V46, P615, DOI 10.1002/1097-0142(19800801)46:3<615::AID-CNCR2820460331>3.0.CO

[2]

2-X

[3]

BAIN BJ, 1981, BLOOD, V58, P206

[4]

BEARMAN RM, 1979, CANCER-AM CANCER SOC, V43, P279, DOI 10.1002/1097-0142(197901)43:1<279::AID-CNCR2820430141>3.0.CO

[5]

2-L

[6]

BERRIDGE MV, 1985, BLOOD, V66, P76

[7] LEUKEMIA OF PLATELET PRECURSORS - DIVERSE FEATURES IN 4 CASES [J].

BEVAN, D ;

ROSE, M ;

GREAVES, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1982, 51 (01) :147-164

[8]

BUHRING HJ, 1989, EUR J HAEMATOL, V42, P143

[9] TRANSLOCATION T(6-9) OCCURRING IN ACUTE MYELOFIBROSIS, MYELODYSPLASTIC SYNDROME, AND ACUTE NONLYMPHOCYTIC LEUKEMIA SUGGESTS MULTIPOTENT STEM-CELL INVOLVEMENT [J].

CUNEO, A ;

KERIM, S ;

VANDENBERGHE, E ;

VANORSHOVEN, A ;

RODHAIN, J ;

BOSLY, A ;

ZACHEE, P ;

LOUWAGIE, A ;

MICHAUX, JL ;

DALCIN, P ;

VANDENBERGHE, H .

CANCER GENETICS AND CYTOGENETICS, 1989, 42 (02) :209-219

[10] MEGAKARYOBLASTIC LEUKEMIA (ACUTE MYELOFIBROSIS) - REPORT OF 3 CASES [J].

DENOTTOLANDER, GJ ;

TEVELDE, J ;

BREDEROO, P ;

GERAEDTS, JPM ;

SLEE, PHT ;

WILLEMZE, R ;

ZWAAN, FE ;

HAAK, HL ;

MULLER, HP ;

BIEGER, R .

BRITISH JOURNAL OF HAEMATOLOGY, 1979, 42 (01) :9-+

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