Co-activation of AMPK and mTORC1 as a new therapeutic option for acute myeloid leukemia

被引：7

作者：

Sujobert, Pierre ^{[1
,2
,3
]}

Tamburini, Jerome ^{[1
,2
,3
]}

机构：

[1] INSERM, U1016, Inst Cochin, CNRS,UMR8104, Paris, France

[2] Univ Paris 05, Fac Med, Sorbonne Paris Cite, Paris, France

[3] Equipe Labellisee Ligue Natl Canc LNCC, Paris, France

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 04期

关键词：

AMPK; AML; GSK621; mTORC1; synthetic lethality;

D O I：

10.1080/23723556.2015.1071303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the therapeutic potential of GSK621, an AMP-activated protein kinase (AMPK) agonist, in acute myeloid leukemia (AML). GSK621-induced cytotoxicity is restricted to AML cells compared to normal hematopoietic progenitors due to a unique synthetic lethal interaction of co-activation of AMPK and mammalian target of rapamycin complex 1 (mTORC1) that involves the stress response pathway. AMPK activation thus represents an attractive perspective for cancer therapy.

引用

页数：3

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